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Year Number of Results
1995 1
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2002 1
2003 1
2004 1
2006 1
2007 1
2010 2
2011 1
2012 3
2013 3
2014 3
2015 5
2016 7
2017 3
2018 5
2019 5
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2022 15
2023 10
2024 15
2025 10

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101 results

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Page 1
Maralixibat in progressive familial intrahepatic cholestasis (MARCH-PFIC): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.
Miethke AG, Moukarzel A, Porta G, Covarrubias Esquer J, Czubkowski P, Ordonez F, Mosca A, Aqul AA, Squires RH, Sokal E, D'Agostino D, Baumann U, D'Antiga L, Kasi N, Laborde N, Arikan C, Lin CH, Gilmour S, Mittal N, Chiou FK, Horslen SP, Huber WD, Jaecklin T, Nunes T, Lascau A, Longpre L, Mogul DB, Garner W, Vig P, Hupertz VF, Gonzalez-Peralta RP, Ekong U, Hartley J, Laverdure N, Ovchinsky N, Thompson RJ. Miethke AG, et al. Lancet Gastroenterol Hepatol. 2024 Jul;9(7):620-631. doi: 10.1016/S2468-1253(24)00080-3. Epub 2024 May 6. Lancet Gastroenterol Hepatol. 2024. PMID: 38723644 Clinical Trial.
Serum biomarkers correlated with liver stiffness assessed in a multicenter study of pediatric cholestatic liver disease.
Leung DH, Devaraj S, Goodrich NP, Chen X, Rajapakshe D, Ye W, Andreev V, Minard CG, Guffey D, Molleston JP, Bass LM, Karpen SJ, Kamath BM, Wang KS, Sundaram SS, Rosenthal P, McKiernan P, Loomes KM, Jensen MK, Horslen SP, Bezerra JA, Magee JC, Merion RM, Sokol RJ, Shneider BL, Alonso E, Bass L, Kelly S, Riordan M, Melin-Aldana H, Bezerra J, Bove K, Heubi J, Miethke A, Tiao G, Denlinger J, Chapman E, Sokol R, Feldman A, Mack C, Narkewicz M, Suchy F, Sundaram SS, Van Hove J, Garcia B, Kauma M, Kocher K, Steinbeiss M, Lovell M, Loomes KM, Piccoli D, Rand E, Russo P, Spinner N, Erlichman J, Stalford S, Pakstis D, King S, Squires R, Sindhi R, Venkat V, Bukauskas K, McKiernan P, Haberstroh L, Squires J, Rosenthal P, Bull L, Curry J, Langlois C, Kim G, Teckman J, Kociela V, Nagy R, Patel S, Cerkoski J, Molleston JP, Bozic M, Subbarao G, Klipsch A, Sawyers C, Cummings O, Horslen SP, Murray K, Hsu E, Cooper K, Young M, Finn L, Kamath BM, Ng V, Quammie C, Putra J, Sharma D, Parmar A, Guthery S, Jensen K, Rutherford A, Lowichik A, Book L, Meyers R, Hall T, Wang KS, Michail S, Thomas D, Goodhue C, Kohli R, Wang L, Soufi N, Thomas D, Karpen S, Gupta N, Romero R, Vos MB, Tory R, Berauer J… See abstract for full author list ➔ Leung DH, et al. Among authors: miethke a. Hepatology. 2023 Feb 1;77(2):530-545. doi: 10.1002/hep.32777. Epub 2022 Nov 3. Hepatology. 2023. PMID: 36069569 Free PMC article.
Bile acids engage the SIPR-STAT3 signaling axis to modulate regulatory T cell responses in fibrosing cholangiopathies.
Kudira R, Yang ZF, Osuji I, Damen MSMA, Yang Vom Hofe A, Singh M, Karns R, Bariya P, Pfuhler L, Mullen M, Taylor A, Ji H, Lages CS, Shi T, Pasula S, Wayman JA, Bernieh A, Zhang W, Chougnet CA, Hildeman DA, Tiao GM, Huppert SS, Subramanian S, Salomonis N, Miraldi ER, Miethke AG. Kudira R, et al. Among authors: miethke ag. J Hepatol. 2025 Nov;83(5):1128-1141. doi: 10.1016/j.jhep.2025.05.032. Epub 2025 Jun 20. J Hepatol. 2025. PMID: 40545044
Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency.
Li CZ, Ogawa H, Ng SS, Chen X, Kishimoto E, Sakabe K, Fukami A, Hu YC, Mayhew CN, Hellmann J, Miethke A, Tasnova NL, Blackford SJI, Tang ZM, Syanda AM, Ma L, Xiao F, Sambrotta M, Tavabie O, Soares F, Baker O, Danovi D, Hayashi H, Thompson RJ, Rashid ST, Asai A. Li CZ, et al. Among authors: miethke a. JHEP Rep. 2022 Feb 1;4(4):100446. doi: 10.1016/j.jhepr.2022.100446. eCollection 2022 Apr. JHEP Rep. 2022. PMID: 35284810 Free PMC article.
A new multisystem ERCC1-hepatorenal syndrome: insights from a clinical cohort, molecular pathogenesis, and management guidelines.
White SM, Wondergem AP, Breet I, Dittmaier M, Bell K, Richmond CM, Hardikar W, Bhatia K, Quinlan C, Orchard D, D'Souza A, Chazin WJ, Smith C, Sparkes R, Lam S, Carter A, Hopkin RJ, Khendek L, Sullivan BR, Becher N, Simonsen AKW, Kvistgaard H, Dempsey K, Miethke AG, Gregersen PA, Phillips E, Luijsterburg MS. White SM, et al. Among authors: miethke ag. Eur J Hum Genet. 2025 Oct;33(10):1252-1263. doi: 10.1038/s41431-025-01910-0. Epub 2025 Jul 19. Eur J Hum Genet. 2025. PMID: 40684071 Free PMC article.
Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts.
Rudman-Melnick V, Vanhoutte D, Stowers K, Sargent M, Adam M, Ma Q, Perl AKT, Miethke AG, Burg A, Shi T, Hildeman DA, Woodle ESS, Kofron JM, Devarajan P. Rudman-Melnick V, et al. Among authors: miethke ag. Sci Rep. 2024 Nov 26;14(1):29307. doi: 10.1038/s41598-024-80930-0. Sci Rep. 2024. PMID: 39592775 Free PMC article.
Macrophages drive a fibrogenic gene program of periductal fibroblasts in pediatric primary sclerosing cholangitis.
Wang Y, Adeleke D, Xie X, Yang Z, von Hofe AY, Singh M, Malik A, Kudira R, Castro-Rojas C, Pfuhler L, Alquraish M, Sylvestre P, Dillman JR, Trout AT, Miraldi E, Miethke AG. Wang Y, et al. Among authors: miethke ag. bioRxiv [Preprint]. 2025 Aug 21:2025.08.14.670195. doi: 10.1101/2025.08.14.670195. bioRxiv. 2025. PMID: 40894696 Free PMC article. Preprint.
Interleukin 8-CXCR2-mediated neutrophil extracellular trap formation in biliary atresia associated with neutrophil extracellular trap-induced stellate cell activation.
Luo Y, Fraser L, Jezykowski J, Gupta NA, Miethke AG, Taylor SA, Alonso EM, Horslen S, Kohli R, Molleston JP, Kamath BM, Guthery SL, Loomes KM, Magee JC, Rosenthal P, Valentino P, Sokol RJ, Mack CL; Childhood Liver Disease Research Network. Luo Y, et al. Among authors: miethke ag. Hepatology. 2025 Sep 1;82(3):552-565. doi: 10.1097/HEP.0000000000001195. Epub 2024 Dec 18. Hepatology. 2025. PMID: 39693274
Maralixibat for the treatment of PFIC: Long-term, IBAT inhibition in an open-label, Phase 2 study.
Loomes KM, Squires RH, Kelly D, Rajwal S, Soufi N, Lachaux A, Jankowska I, Mack C, Setchell KDR, Karthikeyan P, Kennedy C, Dorenbaum A, Desai NK, Garner W, Jaecklin T, Vig P, Miethke A, Thompson RJ. Loomes KM, et al. Among authors: miethke a. Hepatol Commun. 2022 Sep;6(9):2379-2390. doi: 10.1002/hep4.1980. Epub 2022 May 4. Hepatol Commun. 2022. PMID: 35507739 Free PMC article. Clinical Trial.
Fishing for biliary atresia susceptibility genes.
Miethke AG, Huppert SS. Miethke AG, et al. Gastroenterology. 2013 May;144(5):878-81. doi: 10.1053/j.gastro.2013.03.017. Epub 2013 Mar 22. Gastroenterology. 2013. PMID: 23523832 Free PMC article. No abstract available.
101 results