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49 results

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Page 1
Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy.
Finkel RS, Mercuri E, Darras BT, Connolly AM, Kuntz NL, Kirschner J, Chiriboga CA, Saito K, Servais L, Tizzano E, Topaloglu H, Tulinius M, Montes J, Glanzman AM, Bishop K, Zhong ZJ, Gheuens S, Bennett CF, Schneider E, Farwell W, De Vivo DC; ENDEAR Study Group. Finkel RS, et al. N Engl J Med. 2017 Nov 2;377(18):1723-1732. doi: 10.1056/NEJMoa1702752. N Engl J Med. 2017. PMID: 29091570 Free article. Clinical Trial.
Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy.
Mercuri E, Darras BT, Chiriboga CA, Day JW, Campbell C, Connolly AM, Iannaccone ST, Kirschner J, Kuntz NL, Saito K, Shieh PB, Tulinius M, Mazzone ES, Montes J, Bishop KM, Yang Q, Foster R, Gheuens S, Bennett CF, Farwell W, Schneider E, De Vivo DC, Finkel RS; CHERISH Study Group. Mercuri E, et al. N Engl J Med. 2018 Feb 15;378(7):625-635. doi: 10.1056/NEJMoa1710504. N Engl J Med. 2018. PMID: 29443664 Free article. Clinical Trial.
EMT and dissemination precede pancreatic tumor formation.
Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, McAllister F, Reichert M, Beatty GL, Rustgi AK, Vonderheide RH, Leach SD, Stanger BZ. Rhim AD, et al. Among authors: mirek et. Cell. 2012 Jan 20;148(1-2):349-61. doi: 10.1016/j.cell.2011.11.025. Cell. 2012. PMID: 22265420 Free PMC article.
Risdiplam in Type 1 Spinal Muscular Atrophy.
Baranello G, Darras BT, Day JW, Deconinck N, Klein A, Masson R, Mercuri E, Rose K, El-Khairi M, Gerber M, Gorni K, Khwaja O, Kletzl H, Scalco RS, Seabrook T, Fontoura P, Servais L; FIREFISH Working Group. Baranello G, et al. N Engl J Med. 2021 Mar 11;384(10):915-923. doi: 10.1056/NEJMoa2009965. Epub 2021 Feb 24. N Engl J Med. 2021. PMID: 33626251 Clinical Trial.
Risdiplam-Treated Infants with Type 1 Spinal Muscular Atrophy versus Historical Controls.
Darras BT, Masson R, Mazurkiewicz-Bełdzińska M, Rose K, Xiong H, Zanoteli E, Baranello G, Bruno C, Vlodavets D, Wang Y, El-Khairi M, Gerber M, Gorni K, Khwaja O, Kletzl H, Scalco RS, Fontoura P, Servais L; FIREFISH Working Group. Darras BT, et al. N Engl J Med. 2021 Jul 29;385(5):427-435. doi: 10.1056/NEJMoa2102047. N Engl J Med. 2021. PMID: 34320287
[No title available]
Montes J, Young SD, Mazzone E, Main M; International Spinal Muscular Atrophy Consortium Clinical Evaluator Working Group. Montes J, et al. Neuromuscul Disord. 2017 Jul 12:S0960-8966(17)30577-1. doi: 10.1016/j.nmd.2017.07.005. Online ahead of print. Neuromuscul Disord. 2017. PMID: 28917631 No abstract available.
Autophagy Suppresses CCL2 to Preserve Appetite and Prevent Lethal Cachexia.
Ibrahim M, Gomez-Jenkins M, Scheinfeld A, Zhao Z, Lopes EC, Sawant A, Hu Z, Dharani A, Sun M, Siddiqui S, Mirek ET, Abram-Saliba J, Lattime EC, Su X, Janowitz T, Goncalves MD, Dunn SM, Pritykin Y, Anthony TG, Rabinowitz JD, White E. Ibrahim M, et al. Among authors: mirek et. bioRxiv [Preprint]. 2025 Feb 24:2025.02.20.638910. doi: 10.1101/2025.02.20.638910. bioRxiv. 2025. PMID: 40060612 Free PMC article. Preprint.
Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK.
Bowman CE, Neinast MD, Kawakami R, Forelli N, Jang C, Patel J, Blair MC, Noji MC, Mirek ET, Jonsson WO, Chu Q, Merlo L, Mandik-Nayak L, Anthony TG, Rabinowitz JD, Arany Z. Bowman CE, et al. Among authors: mirek et. Mol Metab. 2025 Jul;97:102165. doi: 10.1016/j.molmet.2025.102165. Epub 2025 May 8. Mol Metab. 2025. PMID: 40348014 Free PMC article.
Circulating metabolite homeostasis achieved through mass action.
Li X, Hui S, Mirek ET, Jonsson WO, Anthony TG, Lee WD, Zeng X, Jang C, Rabinowitz JD. Li X, et al. Among authors: mirek et. Nat Metab. 2022 Jan;4(1):141-152. doi: 10.1038/s42255-021-00517-1. Epub 2022 Jan 20. Nat Metab. 2022. PMID: 35058631 Free PMC article.
GCN2 is required to maintain core body temperature in mice during acute cold.
Levy JL, Mirek ET, Rodriguez EM, Zalma B, Burns J, Jonsson WO, Sampath H, Staschke KA, Wek RC, Anthony TG. Levy JL, et al. Among authors: mirek et. Am J Physiol Endocrinol Metab. 2023 Nov 1;325(5):E624-E637. doi: 10.1152/ajpendo.00181.2023. Epub 2023 Oct 4. Am J Physiol Endocrinol Metab. 2023. PMID: 37792040 Free PMC article.
49 results