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The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology.
Trebicka J, Fernandez J, Papp M, Caraceni P, Laleman W, Gambino C, Giovo I, Uschner FE, Jimenez C, Mookerjee R, Gustot T, Albillos A, Bañares R, Janicko M, Steib C, Reiberger T, Acevedo J, Gatti P, Bernal W, Zeuzem S, Zipprich A, Piano S, Berg T, Bruns T, Bendtsen F, Coenraad M, Merli M, Stauber R, Zoller H, Ramos JP, Solè C, Soriano G, de Gottardi A, Gronbaek H, Saliba F, Trautwein C, Özdogan OC, Francque S, Ryder S, Nahon P, Romero-Gomez M, Van Vlierberghe H, Francoz C, Manns M, Garcia E, Tufoni M, Amoros A, Pavesi M, Sanchez C, Curto A, Pitarch C, Putignano A, Moreno E, Shawcross D, Aguilar F, Clària J, Ponzo P, Jansen C, Vitalis Z, Zaccherini G, Balogh B, Vargas V, Montagnese S, Alessandria C, Bernardi M, Ginès P, Jalan R, Moreau R, Angeli P, Arroyo V; PREDICT STUDY group of the EASL-CLIF Consortium. Trebicka J, et al. J Hepatol. 2020 Oct;73(4):842-854. doi: 10.1016/j.jhep.2020.06.013. Epub 2020 Jul 13. J Hepatol. 2020. PMID: 32673741 Free article.
PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis.
Trebicka J, Fernandez J, Papp M, Caraceni P, Laleman W, Gambino C, Giovo I, Uschner FE, Jansen C, Jimenez C, Mookerjee R, Gustot T, Albillos A, Bañares R, Jarcuska P, Steib C, Reiberger T, Acevedo J, Gatti P, Shawcross DL, Zeuzem S, Zipprich A, Piano S, Berg T, Bruns T, Danielsen KV, Coenraad M, Merli M, Stauber R, Zoller H, Ramos JP, Solé C, Soriano G, de Gottardi A, Gronbaek H, Saliba F, Trautwein C, Kani HT, Francque S, Ryder S, Nahon P, Romero-Gomez M, Van Vlierberghe H, Francoz C, Manns M, Garcia-Lopez E, Tufoni M, Amoros A, Pavesi M, Sanchez C, Praktiknjo M, Curto A, Pitarch C, Putignano A, Moreno E, Bernal W, Aguilar F, Clària J, Ponzo P, Vitalis Z, Zaccherini G, Balogh B, Gerbes A, Vargas V, Alessandria C, Bernardi M, Ginès P, Moreau R, Angeli P, Jalan R, Arroyo V; PREDICT STUDY group of the EASL-CLIF CONSORTIUM. Trebicka J, et al. J Hepatol. 2021 May;74(5):1097-1108. doi: 10.1016/j.jhep.2020.11.019. Epub 2020 Nov 20. J Hepatol. 2021. PMID: 33227350 Free article.
Performance of the China-CLIF framework in acute-on-chronic liver failure: a multicohort study across all aetiologies.
Luo J, Hu M, Feng T, Zhang L, Huang Y, Huang Y, Ye F, Li J, Aguilar F, Sánchez-Garrido C, Usón-Raposo E, Zhu B, Zhou Q, Liang X, Li J, Li P, Xin J, Shi D, Zheng J, Zhang H, Wang B, Qiang W, Yao H, Zhou X, Chen J, Hu W, Li B, Ma S, Wu X, Li X, Kong Y, Sun F, Chen X, Wu T, Yang L, Sun S, Guo B, He L, Chen J, Xin S, Li X, Chen H, Angeli P, Jalan R, Lin B, Chen Y, You S, Chen X, Queiroz Farias A, Trebicka J, Jiang J, Moreau R, Li J; CANONIC, PREDICT, ACLARA Study Group; Chinese Group on the Study of Severe Hepatitis B (COSSH). Luo J, et al. Gut. 2025 Aug 7:gutjnl-2025-335651. doi: 10.1136/gutjnl-2025-335651. Online ahead of print. Gut. 2025. PMID: 40713188 Free article.
Gene score to quantify systemic inflammation in patients with acutely decompensated cirrhosis.
Trebicka J, Aguilar F, Queiroz Farias A, Lozano JJ, Sánchez-Garrido C, Usón-Raposo E, de la Peña-Ramirez C, Sidorova J, Curto-Vilalta A, Sierra-Casas P, Momoyo Zitelli P, Papp M, Pereira G, Caraceni P, Goncalves LL, Alessandria C, Torre A, Laleman W, Gadano A, Piano S, Mattos AZ, Gu W, Brol MJ, Schierwagen R, Uschner FE, Fischer J, Mendes LSC, Vargas V, Alvares-da-Silva MR, Mookerjee R, Bittencourt PL, Benitez C, Albillos A, Couto C, Mendizabal M, Bañares R, Toledo CL, Mazo DF, Janicko M, Castillo-Barradas M, Padilla Machaca PM, Gatti P, Miranda AZ, Malé-Velázquez R, Zipprich A, Castro-Lyra A, Gustot T, Bernal W, Gerbes AL, Jalan R, Fernández J, Angeli P, Carrilho FJ, Claria J, Moreau R, Arroyo V; PREDICT study and ACLARA study. Trebicka J, et al. Gut. 2025 Jul 7;74(8):1293-1307. doi: 10.1136/gutjnl-2024-333876. Gut. 2025. PMID: 40011033 Free article.