Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1919 1
1920 1
1947 1
1949 1
1950 1
1951 1
1952 3
1953 2
1954 4
1955 1
1956 2
1957 7
1958 2
1959 7
1960 7
1961 10
1962 10
1963 25
1964 20
1965 15
1966 1
1967 2
1968 2
1969 4
1970 1
1971 5
1972 5
1973 7
1974 14
1975 29
1976 39
1977 45
1978 48
1979 80
1980 120
1981 136
1982 169
1983 303
1984 366
1985 474
1986 589
1987 861
1988 1144
1989 1587
1990 2137
1991 2778
1992 3490
1993 4241
1994 5271
1995 5867
1996 6250
1997 6878
1998 7655
1999 8510
2000 9457
2001 9902
2002 9954
2003 10319
2004 11300
2005 11248
2006 11903
2007 12007
2008 12690
2009 13719
2010 14531
2011 15330
2012 16320
2013 16292
2014 16036
2015 16070
2016 17197
2017 17863
2018 17650
2019 17845
2020 18568
2021 18631
2022 15086
2023 14482
2024 16341
2025 14768
2026 32

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

398,911 results

Results by year

Filters applied: . Clear all
Page 1
Showing results for motif i
Search for Motiul I instead (1 results)
Phase Separation and Neurodegenerative Diseases: A Disturbance in the Force.
Zbinden A, Pérez-Berlanga M, De Rossi P, Polymenidou M. Zbinden A, et al. Dev Cell. 2020 Oct 12;55(1):45-68. doi: 10.1016/j.devcel.2020.09.014. Dev Cell. 2020. PMID: 33049211 Free article. Review.
Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins found in pathological inclusions are known to undergo liquid-liquid phase separation, a reversible process of molecular self-assembly. Emerging evidence supports the hypothesis that aberr …
Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins found in pathological inclusions are known to u …
Affinity and specificity of motif-based protein-protein interactions.
Ivarsson Y, Jemth P. Ivarsson Y, et al. Curr Opin Struct Biol. 2019 Feb;54:26-33. doi: 10.1016/j.sbi.2018.09.009. Epub 2018 Oct 24. Curr Opin Struct Biol. 2019. PMID: 30368054 Review.
It is becoming increasingly clear that eukaryotic cell physiology is largely controlled by protein-protein interactions involving disordered protein regions, which usually interact with globular domains in a coupled binding and folding reaction. Severa …
It is becoming increasingly clear that eukaryotic cell physiology is largely controlled by protein-protein interactions involv …
Emerging Features of Linear Motif-Binding Hub Proteins.
Jespersen N, Barbar E. Jespersen N, et al. Trends Biochem Sci. 2020 May;45(5):375-384. doi: 10.1016/j.tibs.2020.01.004. Epub 2020 Feb 20. Trends Biochem Sci. 2020. PMID: 32311332 Review.
Although this distinguishes some features of hub protein/partner interactions, the increasing literature requires an expanded categorization of molecular and functional properties. ...We propose a new class of structural linear motif-binding hub proteins (LMB-hubs) …
Although this distinguishes some features of hub protein/partner interactions, the increasing literature requires an expanded categor …
Molecular switches in GPCRs.
Filipek S. Filipek S. Curr Opin Struct Biol. 2019 Apr;55:114-120. doi: 10.1016/j.sbi.2019.03.017. Epub 2019 May 10. Curr Opin Struct Biol. 2019. PMID: 31082695 Review.
The switches are usually associated with conserved structural motifs on transmembrane helices (TMs), and they are accompanied by adjacent residues which provide the signal to the central residue in the toggle switch. ...
The switches are usually associated with conserved structural motifs on transmembrane helices (TMs), and they are accompanied by adja …
Modulation of peroxisomal import by the PEX13 SH3 domain and a proximal FxxxF binding motif.
Gaussmann S, Peschel R, Ott J, Zak KM, Sastre J, Delhommel F, Popowicz GM, Boekhoven J, Schliebs W, Erdmann R, Sattler M. Gaussmann S, et al. Nat Commun. 2024 Apr 18;15(1):3317. doi: 10.1038/s41467-024-47605-w. Nat Commun. 2024. PMID: 38632234 Free PMC article.
Strikingly, intramolecular interaction of the PEX13 FxxxF motif regulates binding of PEX5 WxxxF/Y motifs to the PEX13 SH3 domain. Crystal structures reveal how FxxxF and WxxxF/Y motifs are recognized by a non-canonical surface on the SH3 domain. The PEX13 Fxx …
Strikingly, intramolecular interaction of the PEX13 FxxxF motif regulates binding of PEX5 WxxxF/Y motifs to the PEX13 SH3 doma …
Defining short linear motif binding determinants by phage display-based deep mutational scanning.
Benz C, Maassen L, Simonetti L, Mihalic F, Lindqvist R, Tsitsa I, Konstantinou A, Jemth P, Överby AK, Davey NE, Ivarsson Y. Benz C, et al. Protein Sci. 2025 Jun;34(6):e70174. doi: 10.1002/pro.70174. Protein Sci. 2025. PMID: 40411416 Free PMC article.
Comparison with a set of reference motifs from the eukaryotic linear motif (ELM) database confirmed that the DMS by phage display analysis correctly identifies known motif binding determinants and provides novel insights into specificity determinants, includi …
Comparison with a set of reference motifs from the eukaryotic linear motif (ELM) database confirmed that the DMS by phage disp …
Strategies to Develop Inhibitors of Motif-Mediated Protein-Protein Interactions as Drug Leads.
Corbi-Verge C, Garton M, Nim S, Kim PM. Corbi-Verge C, et al. Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:39-60. doi: 10.1146/annurev-pharmtox-010716-104805. Epub 2016 Sep 8. Annu Rev Pharmacol Toxicol. 2017. PMID: 27618737 Review.
Protein-protein interactions are fundamental for virtually all functions of the cell. A large fraction of these interactions involve short peptide motifs, and there has been increased interest in targeting them using peptide-based therapeutics. ...In this rev …
Protein-protein interactions are fundamental for virtually all functions of the cell. A large fraction of these interactions i …
Using Linear Motif Database Resources to Identify SH2 Domain Binders.
Sámano-Sánchez H, Gibson TJ, Chemes LB. Sámano-Sánchez H, et al. Methods Mol Biol. 2023;2705:153-197. doi: 10.1007/978-1-0716-3393-9_9. Methods Mol Biol. 2023. PMID: 37668974
The SH2-binding phosphotyrosine class of short linear motifs (SLiMs) are key conditional regulatory elements, particularly in signaling protein complexes beneath the cell's plasma membrane. ...Researchers can take advantage of bioinformatics tools and resources to p …
The SH2-binding phosphotyrosine class of short linear motifs (SLiMs) are key conditional regulatory elements, particularly in signali …
398,911 results
You have reached the last available page of results. Please see the User Guide for more information.