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1838 1
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1842 1
1855 1
1861 1
1879 1
1880 1
1883 1
1885 1
1887 1
1901 1
1909 1
1910 1
1911 1
1912 3
1913 2
1914 2
1917 2
1918 1
1920 2
1921 1
1922 1
1923 2
1925 3
1926 3
1927 7
1928 8
1929 5
1930 6
1931 3
1932 4
1933 4
1934 1
1935 3
1936 1
1937 2
1938 3
1939 2
1940 1
1944 1
1945 15
1946 48
1947 69
1948 120
1949 106
1950 157
1951 210
1952 178
1953 217
1954 219
1955 238
1956 198
1957 179
1958 219
1959 145
1960 88
1961 106
1962 95
1963 104
1964 82
1965 246
1966 349
1967 455
1968 432
1969 439
1970 474
1971 515
1972 482
1973 510
1974 522
1975 564
1976 554
1977 608
1978 630
1979 624
1980 623
1981 688
1982 682
1983 745
1984 805
1985 841
1986 909
1987 1026
1988 985
1989 1107
1990 1165
1991 1146
1992 1073
1993 1187
1994 1335
1995 1328
1996 1472
1997 1478
1998 1699
1999 1620
2000 1913
2001 1933
2002 2028
2003 2128
2004 2115
2005 2304
2006 2456
2007 2650
2008 2852
2009 2935
2010 3282
2011 3509
2012 3817
2013 3990
2014 3974
2015 4121
2016 4177
2017 4164
2018 4352
2019 4295
2020 4709
2021 5168
2022 4968
2023 4828
2024 4648
2025 4485
2026 12

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114,121 results

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Page 1
The Muller's Ratchet and Aging.
Govindaraju DR, Innan H, Veitia RA. Govindaraju DR, et al. Trends Genet. 2020 Jun;36(6):395-402. doi: 10.1016/j.tig.2020.02.004. Epub 2020 Mar 18. Trends Genet. 2020. PMID: 32396833 Review.
Such deleterious alterations, including epigenetic drift, irreversibly accumulate in a stepwise, ratchet-like manner and reduce cellular fitness, similar to the process known as Muller's ratchet. Here, we revisit the Muller's ratchet principle applied …
Such deleterious alterations, including epigenetic drift, irreversibly accumulate in a stepwise, ratchet-like manner and reduce cellular fit …
Muller's genetic load/species extinction hypothesis.
Calabrese EJ, Selby PB. Calabrese EJ, et al. Environ Res. 2024 Jan 15;241:117599. doi: 10.1016/j.envres.2023.117599. Epub 2023 Nov 10. Environ Res. 2024. PMID: 37952856 Review.
Two major mouse radiation research teams in the United States provided the most extensive tests of Muller's hypothesis. One group continued its study for more than two decades, over 82 consecutive generations, approximating 2500 human years. ...More recent data on i …
Two major mouse radiation research teams in the United States provided the most extensive tests of Muller's hypothesis. One gr …
Muller's Nobel Prize data: Getting the dose wrong and its significance.
Calabrese EJ. Calabrese EJ. Environ Res. 2019 Sep;176:108528. doi: 10.1016/j.envres.2019.108528. Epub 2019 Jun 8. Environ Res. 2019. PMID: 31228809 Review.
Most importantly, this paper reveals that in Muller's (1927) Nobel Prize research he used a treatment exposure (total dose) that was 95 million-fold greater than the average background exposure, a value far greater than the 200,000 fold reported by Muller and …
Most importantly, this paper reveals that in Muller's (1927) Nobel Prize research he used a treatment exposure (total dose) th …
Muller's muscle conjunctival resection versus external levator advancement for ptosis repair: systematic review and meta-analysis.
Karam M, Alsaif A, Abul A, Alkhabbaz A, Alotaibi A, Shareef E, Behbehani R. Karam M, et al. Int Ophthalmol. 2023 Jul;43(7):2563-2573. doi: 10.1007/s10792-023-02633-1. Epub 2023 Jan 24. Int Ophthalmol. 2023. PMID: 36692699
PURPOSE: To compare the outcome of Muller's muscle conjunctival resection (MMCR) versus external levator advancement (ELA) in patients undergoing ptosis surgery. ...
PURPOSE: To compare the outcome of Muller's muscle conjunctival resection (MMCR) versus external levator advancement (ELA) in …
Was Muller's 1946 Nobel Prize research for radiation-induced gene mutations peer-reviewed?
Calabrese EJ. Calabrese EJ. Philos Ethics Humanit Med. 2018 Jun 6;13(1):6. doi: 10.1186/s13010-018-0060-5. Philos Ethics Humanit Med. 2018. PMID: 29875023 Free PMC article. Review.
This historical analysis indicates that it is highly unlikely that the Nobel Prize winning research of Hermann J. Muller was peer-reviewed. The published paper of Muller lacked a research methods section, cited no references, and failed to acknowledge and discuss th …
This historical analysis indicates that it is highly unlikely that the Nobel Prize winning research of Hermann J. Muller was peer-rev …
Muller's Nobel Prize Lecture: when ideology prevailed over science.
Calabrese EJ. Calabrese EJ. Toxicol Sci. 2012 Mar;126(1):1-4. doi: 10.1093/toxsci/kfr338. Epub 2011 Dec 13. Toxicol Sci. 2012. PMID: 22166484 Review.
This paper extends and confirms the report of Calabrese (Calabrese, E. J. (2011b). Muller's Nobel Lecture on dose-response for ionizing radiation: Ideology or science? Arch. ...Recently uncovered private correspondence between Muller and Stern reveals Mull …
This paper extends and confirms the report of Calabrese (Calabrese, E. J. (2011b). Muller's Nobel Lecture on dose-response for …
Muller's Muscle as a Sensory Proprioceptive Organ: Histological and Histochemical Analysis.
Landau-Prat D, Mayer C, Gomel N, Arazi M, Zloto O, Dori A, Ben Simon GJ. Landau-Prat D, et al. Invest Ophthalmol Vis Sci. 2023 May 1;64(5):18. doi: 10.1167/iovs.64.5.18. Invest Ophthalmol Vis Sci. 2023. PMID: 37212780 Free PMC article.
PURPOSE: The purpose of this study was to determine whether proprioceptive nerves are present in Muller's muscle. METHODS: This was a prospective cohort study in which histologic and immunofluorescence analyses of excised Muller's muscle specimens were …
PURPOSE: The purpose of this study was to determine whether proprioceptive nerves are present in Muller's muscle. METHODS: Thi …
OTULIN and Muller's morphs.
Spaan AN. Spaan AN. J Exp Med. 2024 Jun 3;221(6):e20240418. doi: 10.1084/jem.20240418. Epub 2024 Apr 23. J Exp Med. 2024. PMID: 38652463 Free PMC article.
Muller's ratchet of the Y chromosome with gene conversion.
Sakamoto T, Innan H. Sakamoto T, et al. Genetics. 2022 Jan 4;220(1):iyab204. doi: 10.1093/genetics/iyab204. Genetics. 2022. PMID: 34791206 Free PMC article.
Muller's ratchet is a process in which deleterious mutations are fixed irreversibly in the absence of recombination. ...We developed a model of Muller's ratchet to explore the evolution of the Y chromosome. The model assumes a nonrecombining chromosome …
Muller's ratchet is a process in which deleterious mutations are fixed irreversibly in the absence of recombination. ...We dev …
Muller's ratchet and gene duplication.
Freund F, Wirtz J, Zheng Y, Schäfer Y, Wiehe T. Freund F, et al. Theor Popul Biol. 2025 Aug;164:12-22. doi: 10.1016/j.tpb.2025.04.002. Epub 2025 May 13. Theor Popul Biol. 2025. PMID: 40374144 Free article.
Here, we study a model of duplication-selection interaction, which is related to Haigh's mutation-selection model of Muller's ratchet. New gene copies are generated by duplication but fitness of individuals decreases as copy number increases. ...
Here, we study a model of duplication-selection interaction, which is related to Haigh's mutation-selection model of Muller's …
114,121 results
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