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Page 1
Showing results for mrna g
Search for Myrna G instead (1 results)
Emerging mRNA technologies: delivery strategies and biomedical applications.
Xiao Y, Tang Z, Huang X, Chen W, Zhou J, Liu H, Liu C, Kong N, Tao W. Xiao Y, et al. Chem Soc Rev. 2022 May 23;51(10):3828-3845. doi: 10.1039/d1cs00617g. Chem Soc Rev. 2022. PMID: 35437544 Review.
The great success achieved by the two highly-effective messenger RNA (mRNA) vaccines during the COVID-19 pandemic highlights the great potential of mRNA technology. ...Furthermore, typical mRNA delivery platforms for various biomedical applicati …
The great success achieved by the two highly-effective messenger RNA (mRNA) vaccines during the COVID-19 pandemic highl …
METTL1-mediated m(7)G methylation of Sarm1 mRNA promotes macrophage inflammatory responses and multiple organ injury.
Hou C, Zhang XR, Wei J, Wang JN, Gao J, Wang ZJ, Xie SS, Chen T, Sun T, Pu T, Yu JT, Suo XG, Mei ZY, Zhang FR, Jin J, Zhao WM, Shen YX, Meng XM. Hou C, et al. Sci Immunol. 2025 Sep 5;10(111):eadv4810. doi: 10.1126/sciimmunol.adv4810. Epub 2025 Sep 5. Sci Immunol. 2025. PMID: 40911698
RNA modifications regulate phenotype and function of macrophages by regulating RNA translation, splicing, and stability. ...Genetic deletion of METTL1 inhibited macrophage proinflammatory responses. We identified internal Sarm1 messenger RNA (mRNA …
RNA modifications regulate phenotype and function of macrophages by regulating RNA translation, splicing, and stability. ...Ge …
N6-methyladenosine-dependent regulation of messenger RNA stability.
Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, Fu Y, Parisien M, Dai Q, Jia G, Ren B, Pan T, He C. Wang X, et al. Nature. 2014 Jan 2;505(7481):117-20. doi: 10.1038/nature12730. Epub 2013 Nov 27. Nature. 2014. PMID: 24284625 Free PMC article.
N(6)-methyladenosine (m(6)A) is the most prevalent internal (non-cap) modification present in the messenger RNA of all higher eukaryotes. Although essential to cell viability and development, the exact role of m(6)A modification remains to be determined. ...We furth …
N(6)-methyladenosine (m(6)A) is the most prevalent internal (non-cap) modification present in the messenger RNA of all higher …
Branched chemically modified poly(A) tails enhance the translation capacity of mRNA.
Chen H, Liu D, Guo J, Aditham A, Zhou Y, Tian J, Luo S, Ren J, Hsu A, Huang J, Kostas F, Wu M, Liu DR, Wang X. Chen H, et al. Nat Biotechnol. 2025 Feb;43(2):194-203. doi: 10.1038/s41587-024-02174-7. Epub 2024 Mar 22. Nat Biotechnol. 2025. PMID: 38519719 Free PMC article.
Although messenger RNA (mRNA) has proved effective as a vaccine, its potential as a general therapeutic modality is limited by its instability and low translation capacity. ...Here we demonstrate that the optimized multitailed mRNA yielded ~4.7-19.5-fo …
Although messenger RNA (mRNA) has proved effective as a vaccine, its potential as a general therapeutic modality is lim …
EF-G-induced ribosome sliding along the noncoding mRNA.
Klimova M, Senyushkina T, Samatova E, Peng BZ, Pearson M, Peske F, Rodnina MV. Klimova M, et al. Sci Adv. 2019 Jun 5;5(6):eaaw9049. doi: 10.1126/sciadv.aaw9049. eCollection 2019 Jun. Sci Adv. 2019. PMID: 31183409 Free PMC article.
Translational bypassing is a recoding event during which ribosomes slide over a noncoding region of the messenger RNA (mRNA) to synthesize one protein from two discontinuous reading frames. Structures in the mRNA orchestrate forward movement of the rib …
Translational bypassing is a recoding event during which ribosomes slide over a noncoding region of the messenger RNA (mRNA …
IL-7 promotes mRNA vaccine-induced long-term immunity.
Wang L, Wan J, He W, Wang Z, Wu Q, Zhou M, Fu ZF, Zhao L. Wang L, et al. J Nanobiotechnology. 2024 Nov 16;22(1):716. doi: 10.1186/s12951-024-02993-5. J Nanobiotechnology. 2024. PMID: 39550592 Free PMC article.
Messenger RNA (mRNA) vaccines are a key technology in combating existing and emerging infectious diseases. ...Here, we report an adjuvant strategy to enhance the efficacy of mRNA vaccines by co-loading mRNA encoding the antigen (rabies virus gly …
Messenger RNA (mRNA) vaccines are a key technology in combating existing and emerging infectious diseases. ...Here, we …
Safety and Immunogenicity of mRNA-1010, an Investigational Seasonal Influenza Vaccine, in Healthy Adults: Final Results From a Phase 1/2 Randomized Trial.
Ananworanich J, Lee IT, Ensz D, Carmona L, Schaefers K, Avanesov A, Stadlbauer D, Choi A, Pucci A, McGrath S, Kuo HH, Henry C, Chen R, Huang W, Nachbagauer R, Paris R. Ananworanich J, et al. J Infect Dis. 2025 Feb 4;231(1):e113-e122. doi: 10.1093/infdis/jiae329. J Infect Dis. 2025. PMID: 38934845 Free PMC article. Clinical Trial.
BACKGROUND: Seasonal influenza remains a global public health concern. A messenger RNA (mRNA)-based quadrivalent seasonal influenza vaccine, mRNA-1010, was investigated in a first-in-human, phase 1/2 clinical trial conducted in 3 parts. ...When compare …
BACKGROUND: Seasonal influenza remains a global public health concern. A messenger RNA (mRNA)-based quadrivalent season …
Immunogenicity of rabies virus G mRNA formulated with lipid nanoparticles and nucleic acid immunostimulators in mice.
Hongtu Q, BoLi L, Jianguo C, Shusheng P, Ming M. Hongtu Q, et al. Vaccine. 2023 Nov 22;41(48):7129-7137. doi: 10.1016/j.vaccine.2023.10.019. Epub 2023 Oct 20. Vaccine. 2023. PMID: 37866995 Free article.
Rabies is a preventable zoonotic disease caused by rabies virus (RABV) with high mortality. Messenger RNA (mRNA) vaccines have opened up new avenues for vaccine development and pandemic preparedness with potent scalability, which may overcome the only license …
Rabies is a preventable zoonotic disease caused by rabies virus (RABV) with high mortality. Messenger RNA (mRNA) vaccin …
Geneticin reduces mRNA stability.
Durmaz YT, Shatadal A, Friend K. Durmaz YT, et al. PLoS One. 2022 Jul 28;17(7):e0272058. doi: 10.1371/journal.pone.0272058. eCollection 2022. PLoS One. 2022. PMID: 35901009 Free PMC article.
Messenger RNA (mRNA) translation can lead to higher rates of mRNA decay, suggesting the ribosome plays a role in mRNA destruction. Furthermore, mRNA features, such as codon identities, which are directly probed by the ribosome, correlate …
Messenger RNA (mRNA) translation can lead to higher rates of mRNA decay, suggesting the ribosome plays a role in …
COVID-19 mRNA vaccine allergy.
Risma KA. Risma KA. Curr Opin Pediatr. 2021 Dec 1;33(6):610-617. doi: 10.1097/MOP.0000000000001077. Curr Opin Pediatr. 2021. PMID: 34670264 Free PMC article. Review.
PURPOSE OF REVIEW: A known history of a severe allergic reaction (e.g., anaphylaxis) to any component of the vaccine is the only contraindication to coronavirus disease 2019 (COVID-19) mRNA vaccination. It is important for pediatricians to understand the likelihood …
PURPOSE OF REVIEW: A known history of a severe allergic reaction (e.g., anaphylaxis) to any component of the vaccine is the only cont …
61,115 results
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