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Fixed ratio (2:1) prolonged-release oxycodone/naloxone combination improves bowel function in patients with moderate-to-severe pain and opioid-induced constipation refractory to at least two classes of laxatives.
Curr Med Res Opin. 2014 Nov;30(11):2389-96. doi: 10.1185/03007995.2014.971355. Epub 2014 Oct 13.
Curr Med Res Opin. 2014.
PMID: 25265132
Clinical Trial.
A randomized, double-blind, active-controlled, double-dummy, parallel-group study to determine the safety and efficacy of oxycodone/naloxone prolonged-release tablets in patients with moderate/severe, chronic cancer pain.
Ahmedzai SH, Nauck F, Bar-Sela G, Bosse B, Leyendecker P, Hopp M.
Ahmedzai SH, et al.
Palliat Med. 2012 Jan;26(1):50-60. doi: 10.1177/0269216311418869. Epub 2011 Sep 21.
Palliat Med. 2012.
PMID: 21937568
Free PMC article.
Clinical Trial.
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