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Controlled Clinical Trial
. 2015 Jan 10:14:5.
doi: 10.1186/1475-2891-14-5.

Impact of weight loss diet associated with flaxseed on inflammatory markers in men with cardiovascular risk factors: a clinical study

Roberta Soares Lara Cassani, Priscila Giacomo Fassini  1 , Jose Henrique Silvah, Cristiane Maria Mártires Lima, Júlio Sérgio Marchini
Affiliations
Controlled Clinical Trial

Impact of weight loss diet associated with flaxseed on inflammatory markers in men with cardiovascular risk factors: a clinical study

Roberta Soares Lara Cassani et al. Nutr J. .

Retraction in

Abstract

Background: Flaxseed has received attention for its anti-inflammatory and antioxidant role. The present study hypothesizes if flaxseed added to a weight loss diet could improve the lipid and metabolic profiles and decrease risk factors related to cardiovascular disease.

Methods: In a prospective, single blinded 42 days protocol, subjects were allocated into two groups with low carbohydrates intake: GriceLC (35% of carbohydrate and 60g of raw rice powder per day) and GflaxLC (32% of carbohydrate and 60g of flaxseed powder per day). Blood pressure, anthropometric measures and serum levels of isoprostane, C-reactive protein, Tumor Necrosis Factor-alpha, glucose, lipidic profile, uric acid, adiponectin, leptin and insulin were measured at baseline and at the end of interventions. Serum and urinary enterodiol and enterolactione were also measured.

Results: A total of 27 men with cardiovascular risk factors were evaluated, with mean age of 33 ± 10 years to GriceLC and 40 ± 9 years to GflaxLC. Both groups experienced weight loss and systolic blood pressure reduction. A decrease in inflammatory markers (CRP and TNF-α) was observed after flaxseed intake (mean decrease of 25% and 46% for GflaxLC respectively). All groups also showed improvement in levels of total cholesterol, LDL-c, uric acid and adiponectin. Only GflaxLC group showed a decrease in triglyceride levels.

Conclusion: This study suggests that flaxseed added to a weight loss diet could be an important nutritional strategy to reduce inflammation markers such as CRP and TNF-α.

Trial registration: ClinicalTrials.gov NCT02132728.

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Figures

Figure 1
Figure 1
Study flow chart.
Figure 2
Figure 2
Serum and urinary levels of enterodiol and enterolactone according to group and time of assessment. (▲) GriceLC; (●) GflaxLC. *significant difference between initial and final times (p < 0,05).
Figure 3
Figure 3
Serum levels of CRP, TNF-α and isoprostane according to group and time of assessment. (▲) GriceLC; (●) GflaxLC. *significant difference between initial and final times (p < 0,05).
Figure 4
Figure 4
Leptin and adiponectin levels according to group and time of assessment. (▲) GriceLC; (●) GflaxLC. *significant difference between initial and final times (p < 0,05).
See this image and copyright information in PMC

References

    1. Hansson GK. Immune mechanisms in atherosclerosis. Arterioscl Throm Vas. 2001;21:1876–1890. doi: 10.1161/hq1201.100220. - DOI - PubMed
    1. Couillard C, Ruel G, Archer WR, Pomerleau S, Bergeron J, Couture P, Lamarche B, Bergeron N. Circulating levels of oxidative stress markers and endothelial adhesion molecules in men with abdominal obesity. J Clin Endocr Metab. 2005;90:6454–6459. doi: 10.1210/jc.2004-2438. - DOI - PubMed
    1. Paschos G, Zampelas A, Panagiotakos DB, Katsiougiannis S, Griffin B, Votteas V, Skopouli FN. Effects of flaxseed oil supplementation on plasma adiponectin levels in dyslipidemic men. Eur J Nutr. 2007;46:315–320. doi: 10.1007/s00394-007-0668-5. - DOI - PubMed
    1. Shoelson SE, LEE J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest. 2006;116:1793–1801. doi: 10.1172/JCI29069. - DOI - PMC - PubMed
    1. Fantuzzi G, Mazzone T. Adipose tissue and atherosclerosis. Exploring the connection. Arterioscl Throm Vas. 2007;27:996–1003. doi: 10.1161/ATVBAHA.106.131755. - DOI - PubMed

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