Psychosocial interventions for self-harm in adults
- PMID: 33884617
- PMCID: PMC8094743
- DOI: 10.1002/14651858.CD013668.pub2
Psychosocial interventions for self-harm in adults
Abstract
Background: Self-harm (SH; intentional self-poisoning or self-injury regardless of degree of suicidal intent or other types of motivation) is a growing problem in most counties, often repeated, and associated with suicide. There has been a substantial increase in both the number of trials and therapeutic approaches of psychosocial interventions for SH in adults. This review therefore updates a previous Cochrane Review (last published in 2016) on the role of psychosocial interventions in the treatment of SH in adults.
Objectives: To assess the effects of psychosocial interventions for self-harm (SH) compared to comparison types of care (e.g. treatment-as-usual, routine psychiatric care, enhanced usual care, active comparator) for adults (aged 18 years or older) who engage in SH.
Search methods: We searched the Cochrane Common Mental Disorders Specialised Register, the Cochrane Library (Central Register of Controlled Trials [CENTRAL] and Cochrane Database of Systematic reviews [CDSR]), together with MEDLINE, Ovid Embase, and PsycINFO (to 4 July 2020).
Selection criteria: We included all randomised controlled trials (RCTs) comparing interventions of specific psychosocial treatments versus treatment-as-usual (TAU), routine psychiatric care, enhanced usual care (EUC), active comparator, or a combination of these, in the treatment of adults with a recent (within six months of trial entry) episode of SH resulting in presentation to hospital or clinical services. The primary outcome was the occurrence of a repeated episode of SH over a maximum follow-up period of two years. Secondary outcomes included treatment adherence, depression, hopelessness, general functioning, social functioning, suicidal ideation, and suicide.
Data collection and analysis: We independently selected trials, extracted data, and appraised trial quality. For binary outcomes, we calculated odds ratio (ORs) and their 95% confidence intervals (CIs). For continuous outcomes, we calculated mean differences (MDs) or standardised mean differences (SMDs) and 95% CIs. The overall quality of evidence for the primary outcome (i.e. repetition of SH at post-intervention) was appraised for each intervention using the GRADE approach.
Main results: We included data from 76 trials with a total of 21,414 participants. Participants in these trials were predominately female (61.9%) with a mean age of 31.8 years (standard deviation [SD] 11.7 years). On the basis of data from four trials, individual cognitive behavioural therapy (CBT)-based psychotherapy may reduce repetition of SH as compared to TAU or another comparator by the end of the intervention (OR 0.35, 95% CI 0.12 to 1.02; N = 238; k = 4; GRADE: low certainty evidence), although there was imprecision in the effect estimate. At longer follow-up time points (e.g., 6- and 12-months) there was some evidence that individual CBT-based psychotherapy may reduce SH repetition. Whilst there may be a slightly lower rate of SH repetition for dialectical behaviour therapy (DBT) (66.0%) as compared to TAU or alternative psychotherapy (68.2%), the evidence remains uncertain as to whether DBT reduces absolute repetition of SH by the post-intervention assessment. On the basis of data from a single trial, mentalisation-based therapy (MBT) reduces repetition of SH and frequency of SH by the post-intervention assessment (OR 0.35, 95% CI 0.17 to 0.73; N = 134; k = 1; GRADE: high-certainty evidence). A group-based emotion-regulation psychotherapy may also reduce repetition of SH by the post-intervention assessment based on evidence from two trials by the same author group (OR 0.34, 95% CI 0.13 to 0.88; N = 83; k = 2; moderate-certainty evidence). There is probably little to no effect for different variants of DBT on absolute repetition of SH, including DBT group-based skills training, DBT individual skills training, or an experimental form of DBT in which participants were given significantly longer cognitive exposure to stressful events. The evidence remains uncertain as to whether provision of information and support, based on the Suicide Trends in At-Risk Territories (START) and the SUicide-PREvention Multisite Intervention Study on Suicidal behaviors (SUPRE-MISS) models, have any effect on repetition of SH by the post-intervention assessment. There was no evidence of a difference for psychodynamic psychotherapy, case management, general practitioner (GP) management, remote contact interventions, and other multimodal interventions, or a variety of brief emergency department-based interventions.
Authors' conclusions: Overall, there were significant methodological limitations across the trials included in this review. Given the moderate or very low quality of the available evidence, there is only uncertain evidence regarding a number of psychosocial interventions for adults who engage in SH. Psychosocial therapy based on CBT approaches may result in fewer individuals repeating SH at longer follow-up time points, although no such effect was found at the post-intervention assessment and the quality of evidence, according to the GRADE criteria, was low. Given findings in single trials, or trials by the same author group, both MBT and group-based emotion regulation therapy should be further developed and evaluated in adults. DBT may also lead to a reduction in frequency of SH. Other interventions were mostly evaluated in single trials of moderate to very low quality such that the evidence relating to the use of these interventions is inconclusive at present.
Trial registration: ClinicalTrials.gov NCT00081367 NCT01342809 NCT02505373 NCT01081314 NCT01308151 NCT00736918 NCT00664872 NCT00183651 NCT00154154 NCT01193205 NCT00700089 NCT01176929 NCT01355848 NCT02414763 NCT01123174 NCT01512602 NCT03720730 NCT02004145 NCT01334541 NCT02914847 NCT00714311 NCT02936700 NCT03114917 NCT03011190 NCT03488602 NCT01356186 NCT01473771 NCT02718248 NCT01901887 NCT01689909 NCT00218725 NCT00601939 NCT00603421 NCT00641498 NCT00980824 NCT01359761 NCT01823120 NCT01952405 NCT02227160 NCT02299440 NCT02522143 NCT02742922 NCT03300596 NCT03376113 NCT03489382 NCT03533075 NCT03600532 NCT03943862 NCT03373916 NCT02038075 NCT02685943 NCT02377011 NCT02326883 NCT02985047 NCT00533117 NCT00834834 NCT02106949 NCT02664701 NCT02387736 NCT02060448 NCT02354183 NCT03081078 NCT03185026 NCT03427190 NCT03463980 NCT03541824 NCT03732300 NCT03853382 NCT03894462 NCT04072666 NCT04168645 NCT04191122 NCT04244786 NCT04284085 NCT04343703 NCT04366466 NCT04420546.
Copyright © 2021 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Conflict of interest statement
KGW: is an editor for the Cochrane Common Mental Disorders Group, and senior editor for the Self‐Harm and Suicide Satellite of the group. SEH: is the joint co‐ordinating editor of the Cochrane Common Mental Disorders Group. She is funded by an Auckland Medical Research Foundation Douglas Goodfellow Repatriation Fellowship to develop and test a digital intervention for young people who engage in self‐harm. She is the Principal Clinical Advisor of the Suicide Prevention Office of the Ministry of Health for the New Zealand Government. GR: no declarations of interest to report in relation to this review PH: no declarations of interest to report in relation to this review TLTS: no declarations of interest to report in relation to this review ET: no declarations of interest to report in relation to this review KH: no declarations of interest to report in relation to this review
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Update of
- doi: 10.1002/14651858.CD013668
References
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Vaiva 2018 {published data only}
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- Demesmaeker A, Benard V, Leroy A, Vaiva G. Impacts of a brief contact intervention in suicide prevention on medical care consumptions [Impacts d'un système de veille en prévention du suicide sur les consommations de soins]. L'Encéphale 2019;45:S27-31. - PubMed
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- Vaiva G, Berrouiguet S, Walter M, Courtet P, Ducrocq F, Jardon V, et al. Combining postcards, crisis cards, and telephone contact into a decision-making algorithm to reduce suicide reattempt: a randomized clinical trial of a personalized brief contact intervention. Journal of Clinical Psychiatry 2018;79:17m11631. - PubMed
Van der Sande 1997 {published data only}
-
- Van der Sande R, Buskens E, Van der Graaf Y, Van Rooijen E, Allart E, Van Engeland H. No measurable effect from general socio-psychiatric care for those attempting suicide: a randomized experiment [Geen meetbaar effect van algemene sociaal–psychiatrische nazorg voor suicidepogers; een gerandomiseerd experiment]. Nederlands Tijdschriftvoor de Geneeskunde 1998;142:2356.
-
- Van der Sande R, Van Rooijen L, Buskens E, Allart E, Hawton K, Van der Graaf Y, et al. Intensive in-patient and community intervention versus routine care after attempted suicide. A randomised controlled intervention study. British Journal of Psychiatry 1997;171:35-41. - PubMed
Van Heeringen 1995 {published data only}
-
- Van Heeringen C, Jannes S, Buylaert W, Hendrick H, De Bacquer D, Van Remoortel J. The management of noncompliance with referral to out-patient after-care among attempted suicide patients: a controlled intervention study. Psychological Medicine 1995;25:963-70. - PubMed
Walton 2020 {published and unpublished data}
-
- Walton CJ, Bendit N, Baker AL, Carter GL, Lewin TJ. A randomised trial of dialectical behaviour therapy and the conversational model for the treatment of borderline personality disorder with recent suicidal and/or non-suicidal self-injury: an effectiveness study in an Australian public mental health service. Australian and New Zealand Journal of Psychiatry 2020;54:1020-34. - PubMed
Wang 2016 {published data only}
-
- Wang Y-C, Hsieh L-Y, Wang M-Y, Chou C-H, Huang M-W, Ko H-C. Coping card usage can further reduce suicide reattempt in suicide attempter case management within 3-month intervention. Suicide and Life-Threatening Behavior 2016;46:106-20. - PubMed
Waterhouse 1990 {published data only}
-
- Waterhouse J, Platt S. General hospital admission in the management of parasuicide. A randomised controlled trial. British Journal of Psychiatry 1990;156:236–42. - PubMed
Wei 2013 {published data only}
-
- Wei S, Liu L, Bi B, Li H, Hou J, Tan S, et al. An intervention and follow-up study following a suicide attempt in the emergency departments of four general hospitals in Shenyang, China. Crisis 2013;34:107-15. - PubMed
Weinberg 2006 {published data only}
-
- Weinberg I, Gunderson JG, Hennen J, Cutter CJ. Manual assisted cognitive treatment for deliberate self-harm in borderline personality disorder patients. Journal of Personality Disorders 2006;20:482-92. - PubMed
Welu 1977 {published data only}
-
- Welu T. A follow-up program for suicide attempters: evaluation of effectiveness. Suicide and Life-Threatening Behavior 1977;7:17-30. - PubMed
References to studies excluded from this review
Agyapong 2016 {published data only}
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- Agyapong V, Behre T, Juhas M, Greenshaw A. Preventing self-harm and reducing suicidal ideation through an expediated regular supportive psychotherapy and assertive case management - protocol for a three-armed partial randomised controlled trial. European Psychiatry 2016;33S:S440.
Ahmed 2016 {published data only}ISRCTN76914248
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- Ahmed N, John A, Islam S, Jones R, Anderson P, Davies C, et al. Investigating the feasibility of an enhanced contact intervention in self-harm and suicidal behaviour: a protocol for a randomised controlled trial delivering a Social support and Wellbeing Intervention following Self-Harm (SWISH). British Medical Journal Open 2016;6:e012043. - PMC - PubMed
Albuixech‐García 2020 {published data only}
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- Albuixech-García R, Juliá-Sanchis R, Molina MAF, Escribano S. Impact of the mental health care continuity-chain among individuals expressing suicidal behaviour in a Spanish sample. Issues in Mental Health Nursing 2020;41:602-7. - PubMed
Andover 2015 {published data only}
Andover 2017 {published data only}
Andreasson 2016 {published data only}
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- Andreasson K, Krough J, Rosenbaum B, Gluud C, Jobes DA, Nordentoft M. The DiaS trial: Dialectical behavior therapy versus collaborative assessment and management of Suicidality on self-harm in patients with a recent suicide attempt and borderline personality disorder traits - study protocol for a randomized controlled trial. Trials 2014;15:194. - PMC - PubMed
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- Andreasson K, Krough J, Wenneberg C, Jessen HKL, Krakauer K, Gluud C, et al. Effectiveness of dialectical behavior therapy versus collaborative assessment and management of suicidality treatment for reduction of self-harm in adults with borderline personality traits and disorder - randomized observer-blinded clinical trial. Depression and Anxiety 2016;33:520-30. - PubMed
Andreoli 2019 {published data only}
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- Andreoli A, Burnand Y, Frambati L, Manning D, Frances A. Abandonment psychotherapy and psychosocial functioning among suicidal patients with borderline personality disorder: a 3-year naturalistic follow-up. Journal of Personality Disorders 2019;33:423-36. - PubMed
Barnes 2018 {published data only}
Barnhofer 2015 {published data only}ISRCTN97185214
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- Barnhofer T, Crane C, Brennan K, Duggan DS, Crane RS, Eames C, et al. Mindfulness-based cognitive therapy (MBCT) reduces the association between depressive symptoms and suicidal cognitions in patients with a history of suicidal depression. Journal of Consulting and Clinical Psychology 2015;83:1013-20. - PMC - PubMed
Bateman 2020 {published data only}
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- Bateman A, Constantinou MP, Fonagy P, Holzer S. Eight-year prospective follow-up of mentalization-based treatment versus structured clinical management for people with borderline personality disorder. Personality Disorders: Theory, Research, and Treatment 2020 Jun 25 [EPub ahead of print]. [DOI: 10.1037/per0000422] - DOI - PubMed
Bentley 2017 {published data only}
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- Bentley KH, Sauer-Zavala S, Cassiello-Robbins CF, Conklin LR, Vento S, Homer D. Treating suicidal thoughts and behaviors within an emotional disorders framework: acceptability and feasibility of the unified protocol in an inpatient setting. Behavior Modification 2017;41:529-57. - PubMed
Berrouiguet 2019 {published data only}
Betz 2020 {published and unpublished data}
Bryan 2017a {published data only (unpublished sought but not used)}
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- Bryan CJ, May AM, Rozek DC, Williams SR, Clemans TA, Mintz J, et al. Use of crisis management interventions among suicidal patients: results of a randomized controlled trial. Depression and Anxiety 2018;35:619-28. - PubMed
Bryan 2017b {published data only}
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- Bryan CJ, Mintz J, Clemans TA, Leeson B, Burch S, Williams SR, et al. Effect of crisis response planning vs. contracts for safety on suicide risk in U.S. army soldiers: a randomized clinical trial. Journal of Affective Disorders 2017;212:64-72. - PubMed
Cebria 2015 {published data only}
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- Cebrià AI, Pérez-Bonaventura I, Cuijpers P, Kerkhof A, Parra I, Escayola A, et al. Telephone management program for patients discharged from an emergency department after a suicide attempt: a 5-year follow-up study in a Spanish population. Crisis 2015;36(5):345-52. - PubMed
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- Cebrià AI, Parra I, Pàmias M, Escayola A, García-Parés G, Puntí J, et al. Effectiveness of a telephone management programme for patients discharged from an emergency department after a suicide attempt: controlled study in a Spanish population. Journal of Affective Disorders 2013;147:269-76. - PubMed
Celano 2017 {published and unpublished data}
Currier 2015 {published data only}
-
- Currier GW, Brown GK, Brenner LA, Chesin M, Knox KL, Ghahramanlou-Holloway M, et al. Rationale and study protocol for a two-part intervention: safety planning and structured follow-up among veterans at risk for suicide and discharged from the emergency department. Contemporary Clinical Trials 2015;43:179-84. - PubMed
Dassa 2018 {published data only (unpublished sought but not used)}
-
- Dassa D, Olie E, Courtet P, Ducasse D. Positive psychology for management of suicidal patients: a controlled trial. European Psychiatry 2018;48S:S446.
Davidson 2006 {published and unpublished data}
-
- Davidson K, Norrie J, Tyrer P, Gumley A, Tata P, Murray H, et al. The effectiveness of cognitive behavior therapy for borderline personality disorder: results from the borderline personality disorder study of cognitive therapy (BOSCOT) trial. Journal of Personality Disorders 2006;20:450-65. - PMC - PubMed
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- Davidson KM, Tyrer P, Norrie J, Palmer SJ, Tyrer H. Cognitive therapy v. usual treatment for borderline personality disorder: prospective 6-year follow-up. British Journal of Psychiatry 2010;197:456-62. - PubMed
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- Norrie J, Davidson K, Tata P, Gumley A. Influence of therapist competence and quantity of cognitive behavioural therapy on suicidal behaviour and inpatient hospitalisation in a randomised controlled trial in borderline personality disorder: further analyses of treatment effects in the BOSCOT study. Psychology and Psychotherapy: Theory, Research and Practice 2013;86:280-93. - PMC - PubMed
Dimeff 2020 {published data only}
-
- Dimeff LA, Jobes DA, Chalker SA, Piehl BM, Duvivier LL, Lok BC, et al. A novel engagement of suicidality in the emergency department: Virtual Collaborative Assessment and Management of Suicidality. General Hospital Psychiatry 2020;63:119-26. - PubMed
Di Simplicio 2020 {published data only}
Dixon‐Gordon 2015 {published data only}
-
- Dixon KL, Chapman AL, Turner BJ. A preliminary pilot study comparing dialectical behavior therapy emotion regulation skills with interpersonal effectiveness skills and a control group treatment. Journal of Experimental Psychopathology 2015;6:369-88.
Doering 2010 {published data only}
-
- Buchheim A, Hörz-Sagstetter S, Doering S, Rentrop M, Schuster P, Buchheim P, et al. Change of unresolved attachment in borderline personality disorder: RCT study of transference-focused psychotherapy. Psychotherapy and Psychosomatics 2017;86:314-6. - PubMed
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- Doering S, Hörz S, Rentrop M, Fischer-Kern M, Schuster P, Benecke C, et al. Transference-focused psychotherapy v. treatment by community psychotherapists for borderline personality disorder: randomised controlled trial. British Journal of Psychiatry 2010;196:389-95. - PubMed
Ducasse 2018 {published data only (unpublished sought but not used)}
-
- Ducasse D, Jaussent I, Arpon-Brand V, Vienot M, Laglaoui C, Béziat S, et al. Acceptance and commitment therapy for the management of suicidal patients: a randomized controlled trial. Psychotherapy and Psychosomatics 2018;87:1-12. - PubMed
Exbrayat 2017 {published data only}
Franklin 2016 {published data only}
-
- Franklin JC, Fox KR, Franklin CR, Kleiman EM, Ribeiro JD, Jaroszewski AC, et al. A brief mobile app reduces nonsuicidal and suicidal self-injury: evidence from three randomized controlled trials. Journal of Consulting and Clinical Psychology 2016;84:544-57. - PubMed
Gabilondo 2020 {published data only}
-
- Gabilondo A, Aristegi E, Gonzalez-Pinto A, Zurimendi JM, Mateos del Pinto M, Roca R, et al. Prevention of suicidal behaviour with telemedicine in patients with a recent suicide attempt: is a 6-month intervention long enough? Suicide and Life-Threatening Behavior 2020;50:211-9. - PubMed
Galfalvy 2017 {published data only (unpublished sought but not used)}
-
- Galfalvy H, Brodsky B, Oquendo M, Stanley B. Childhood maltreatment moderates antidepressant treatment response for self-injury in borderline personality disorder. Biological Psychiatry 2017;81:S74.
Gooding 2020 {published data only}ISRCTN17776666
Goodman 2016 {published data only (unpublished sought but not used)}
-
- Goodman M, Banthin D, Blair NJ, Mascitelli KA, Wilsnack J, Chen J, et al. A randomized trial of dialectical behavior therapy in high-risk suicidal veterans. Journal of Clinical Psychiatry 2016;77:e1591-600. - PubMed
Goodman 2020 {published data only}
Haddock 2019 {published data only (unpublished sought but not used)}ISRCTN17890126
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- Haddock G, Davies L, Evans E, Emsley R, Gooding P, Heaney L, et al. Investigating the feasibility and acceptability of a cognitive behavioural suicide prevention therapy for people in acute psychiatric wards (the 'INSITE' trial): study protocol for a randomised controlled trial. Trials 2016;17:79. - PMC - PubMed
Hashemi‐Aliabadi 2020 {published data only}
Hooley 2014 {published data only}
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- Hooley JM, St Germain SA. Nonsuicidal self-injury, pain, and self-criticism: does changing self-worth change pain endurance in people who engage in self-injury. Clinical Psychological Science 2014;2:297-305.
Hooley 2018 {published data only}ISRCTN12276176
Hurtado‐Santiago 2018 {published data only}
Inder 2015 {published data only}
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- Inder ML, Crowe MT, Luty SE, Carter JD, Moor S, Frampton CM, et al. Randomized, controlled trial of interpersonal and social rhythm therapy for young people with bipolar disorder. Bipolar Disorder 2015;17:128-38. - PubMed
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- Inder ML, Crowe MT, Luty SE, Carter JD, Moor S, Frampton CM. Prospective rates of suicide attempts and nonsuicidal self-injury by young people with bipolar disorder participating in a psychotherapy study. Australian and New Zealand Journal of Psychiatry 2015;50:167-73. - PubMed
ISRCTN10115835 {unpublished data only}10115835
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- ISRCTN10115835. Is a talking therapy, called psychodynamic interpersonal therapy, clinically and cost effective for women who self-harm in prison? [Women Offenders Repeat Self-Harm Intervention Pragmatic Trial (WORSHIP III)]. doi.org/10.1186/ISRCTN10115835 (first received 11 February 2019). [DOI: 10.1186/ISRCTN10115835] - DOI
ISRCTN16003313 {unpublished data only}16003313
-
- ISRCTN16003313. A brief psychological intervention for self-harm in emergency departments [ASsuRED: Improving outcomes in patients who self-harm. Adapting and evaluating a brief pSychological inteRvention in Emergency Departments]. doi.org/10.1186/ISRCTN16003313 (first received 27 January 2020).
ISRCTN16049211 {unpublished data only}16049211
-
- ISRCTN16049211. FReSH START feasibility study [Function REplacement in repeated Self-Harm: Standardising Therapeutic Assessment and the Related Therapy (FRESH START): feasibility study]. doi.org/10.1186/ISRCTN16049211 (first received 9 December 2019).
ISRCTN16862589 {unpublished data only}16862589
-
- ISRCTN16862589. Brief education supported treatment for adolescent borderline personality disorder [Brief Education Supported Treatment (BEST) for adolescent borderline personality disorder: a feasibility study of delivery of specialised early intervention for borderline personality disorder through collaboration with education providers, incorporating a feasibility randomised controlled trial]. doi.org/10.1186/ISRCTN16862589 (first received 28 January 2019).
ISRCTN18761534 {unpublished data only}18761534
-
- ISRCTN18761534. Women Offenders Repeat Self-Harm Intervention Pilot II (WORSHIP II). doi.org/10.1186/ISRCTN18761534 (first received 19 December 2012).
Jardon 2019 {published data only}
-
- Jardon V, Debien C, Duhem S, Morgiève M, Ducrocq F, Vaiva G. An example of post-discharge monitoring after a suicide attempt: VigilanS [Un example de système de veille post-hospitalière des suicidants: VigilanS]. L'Éncéphale 2019;45:S13-21. - PubMed
Jobes 2017 {published data only}
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- Huh D, Jobes DA, Comtois KA, Kerbrat AH, Chalker SA, Gutierrez PM, et al. The Collaborative Assessment and Management of Suicidality (CAMS) versus Enhanced Care As Usual (E-CAU) with suicidal soldiers: moderator analyses from a randomized controlled trial. Military Psychology 2018;30:495-506.
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- Jobes DA, Comtois KA, Gutierrez PM, Brenner LA, Huh D, Chalker SA, et al. A randomized controlled trial of the Collaborative Assessment and Management of Suicidality versus Enhanced Care As Usual with suicidal soldiers. Psychiatry 2017;80:339-56. - PubMed
Johnson 2018 {published data only}
-
- Johnson SB, Goodnight BL, Zhang H, Daboin I, Patterson B, Kaslow NJ. Compassion-based mediation in African Americans: self-criticism mediates changes in depression. Suicide and Life-Threatening Behavior 2018;48:160-8. - PubMed
Kawanishi 2018 {published data only}
-
- Kawanishi C, Ishii T, Yonemoto N, Yamada M, Tachikawa H, Kishimoto T, et al. Protocol for a prospective multicentre registry cohort study on suicide attempters given the assertive case management intervention after admission to an emergency department in Japan: Post-ACtion-J Study (PACS). British Medical Journal Open 2018;8:e020517. - PMC - PubMed
Kennedy 2018 {published data only}
Kholodkov 2015 {published data only}
-
- Kholodkov T. Mindfulness-Based Relapse Prevention for Non-Suicidal Self-Injury [Doctor of Philosophy thesis]. Laramie, WY: University of Wyoming, 2015.
Kim 2020 {published data only}
Kline 2016 {published data only}
-
- Kline A, Chesin M, Latorre M, Miller R, St Hill L, Shcherbakov A, et al. Rationale and study design of a trial of mindfulness-based cognitive therapy for preventing suicidal behavior (MBCT-S) in military veterans. Contemporary Clinical Trials 2016;50:245-52. - PubMed
Korczak 2020 {published data only}
LaCroix 2018 {published and unpublished data}
-
- Ghahramanlou-Holloway M, LaCroix JM, Perera KU, Neely L, Grammer G, Weaver J, et al. Inpatient psychiatric care following a suicide-related hospitalization: a pilot trial of post-admission cognitive therapy in a military medical center. General Hospital Psychiatry 2020;63:46-53. - PubMed
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- LaCroix JM, Perera KU, Neely LL, Grammer G, Weaver J, Ghahramanlou-Holloway M. Pilot trial of post-admission cognitive therapy: inpatient program for suicide prevention. Psychological Services 2018;15:279-88. - PubMed
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- Neely L, Irwin K, Carreno Ponce JT, Perera K, Grammer G, Ghahramanlou-Holloway M. Post Admission Cognitive Therapy (PACT) for the prevention of suicide in military personnel with histories of trauma: treatment development and case example. Clinical Case Studies 2013;12:457-73.
Lahoz 2016 {published data only}
-
- Lahoz T, Hvid M, Wang AG. Preventing repetition of attempted suicide - III. The Amager Project, 5-year follow-up of a randomized controlled trial. Nordic Journal of Psychiatry 2017;70:547-53. - PubMed
Lin 2019 {published data only}
-
- Lin T-J, Ko H-C, Wu KY-W, Oei TP, Lane H-Y, Chen C-H. The effectiveness of dialectical behavior therapy skills training group vs. cognitive therapy group on reducing depression and suicide attempts for borderline personality disorder in Taiwan. Archives of Suicide Research 2019;23:82-99. - PubMed
Luxton 2014 {published data only}
-
- Luxton DD, Thomas EK, Chipps J, Relova RM, Brown D, McLay R, et al. Caring letters for suicide prevention: implementation of a multi-site randomized clinical trial in the U.S. military and veteran affairs healthcare systems. Contemporary Clinical Trials 2014;37:252-60. - PubMed
Mackie 2017 {published data only}
Marriott 2016 {published data only}
-
- Marriott BP, Hibbeln JR, Killeen TK, Magruder KM, Holes-Lewis K, Tolliver BK, et al. Design and methods for the Better Resiliency Among Veterans and non-Veterans with Omega-3's (BRAVO) study: A double-blind, placebo-controlled trial of omega-3 fatty acid supplementation among adult individuals at risk of suicide. Contemporary Clinical Trials 2016;47:325-33. - PubMed
Matsubara 2019 {published data only}
-
- Matsubara T, Matsuo K, Matsuda A, Ogino Y, Hobara T, Wakabayashi Y, et al. Combining phone and postcard brief contact interventions for preventing suicide reattempts: a quasi-randomized controlled trial. Psychiatry Research 2019;279:395-6. - PubMed
McCall 2019 {published data only}
-
- McCall WV, Ahn E, Benca R, Krystal A, Rosenquist PB, Rumble M, et al. 0960. A preliminary report from the "REST-IT" study: insomnia severity and hypersomnia severity each independently predict the intensity of suicidal ideation. Sleep 2015;38:A339.
McManama O'Brien 2018 {published data only}
-
- McManama O'Brien KH, Sellers CM, Battalen AW, Ryan CA, Maneta EK, Aguinaldo LD, et al. Feasibility, acceptability, and preliminary effects of a brief alcohol intervention for suicidal adolescents in inpatient psychiatric treatment. Journal of Substance Abuse Treatment 2018;94:105-12. - PubMed
Miller 2016 {published data only}
Morley 2014 {published data only}
-
- Morley KC, Sitharthan G, Haber PS, Tucker P, Sitharthan T. The efficacy of an Opportunistic Cognitive Behavioral intervention package (OCB) on substance use and comorbid suicide risk: a multisite randomized controlled trial. Journal of Consulting and Clinical Psychology 2014;82:130-40. - PubMed
Navarro‐Haro 2018 {published and unpublished data}
-
- Navarro-Haro MV, Botella C, Guillen V, Moliner R, Marco H, Jorquera M, et al. Dialectical behavior therapy in the treatment of borderline personality disorder and eating disorders comorbidity: a pilot study in a naturalistic setting. Cognitive Therapy and Research 2018;42:636-49.
NCT00218725 {unpublished data only}
-
- NCT00218725. Cognitive therapy for suicide attempters with drug dependence disorder. clinicaltrials.gov/ct2/show/NCT00218725 (first received 22 September 2005).
NCT00601939 {unpublished data only}
-
- NCT00601939. Group interventions for abused, suicidal black women. clinicaltrials.gov/ct2/show/NCT00601939 (first received 28 January 2008).
NCT00603421 {unpublished data only}
-
- NCT00603421. Effectiveness of a 24 hour phone line on the rate of suicide attempts in borderline patients. clinicaltrials.gov/ct2/show/NCT00603421 (first received 29 January 2008).
NCT00641498 {unpublished data only}
-
- NCT00641498. Effectiveness of standard emergency department psychiatric treatment compared with effectiveness of standard emergency department psychiatric treatment associated with treatment delivery by a suicide prevention center. clinicaltrials.gov/ct2/show/NCT00641498 (first received 24 March 2008).
NCT00980824 {published data only (unpublished sought but not used)}
-
- NCT00980824. ENGAGE - Meeting mental health needs of complex comorbid patients. clinicaltrials.gov/ct2/show/NCT00980824 (first received 21 September 2009).
NCT01359761 {unpublished data only}
-
- NCT01359761. Post Admission Cognitive Therapy (PACT) for the inpatient treatment of military personnel with suicidal behaviors: a multi-site randomized controlled trial. clinicaltrials.gov/ct2/show/NCT01359761 (first received 25 May 2011).
NCT01823120 {unpublished data only}
-
- NCT01823120. Text message intervention to reduce repeat self-harm in patients presenting to the emergency department. clinicaltrials.gov/ct2/show/NCT01823120 (first received 4 April 2013).
NCT01952405 {unpublished data only}
-
- NCT01952405. Efficacy of dialectical behavior therapy in patients with borderline personality disorder: a controlled trial in Taiwan. clinicaltrials.gov/ct2/show/NCT01952405 (first received 30 September 2013).
NCT02227160 {unpublished data only}
-
- NCT02227160. Group interventions for suicidal African Americans. clinicaltrials.gov/ct2/show/NCT02227160 (first received 27 August 2014).
NCT02299440 {unpublished data only}
-
- NCT02299440. Effects of ketamine in the acute phase of suicidal ideation (KETIS). clinicaltrials.gov/ct2/show/NCT02299440 (first received 24 November 2014).
NCT02522143 {unpublished data only}
-
- NCT02522143. College students who self-harm: an intervention study. clinicaltrials.gov/ct2/show/NCT02522143 (first received 13 August 2015).
NCT02742922 {unpublished data only}
-
- NCT02742922. Multicenter RCT to evaluate the clinical and cost-effectiveness of a culturally adapted therapy (C-MAP) in patients with a history of self-harm. clinicaltrials.gov/ct2/show/NCT02742922 (first received 19 April 2016).
NCT03300596 {unpublished data only}
-
- NCT03300596. Suicidal adults with alcohol or drug use problems: a new hospital-based treatment. clinicaltrials.gov/ct2/show/NCT03300596 (first received 3 October 2017).
NCT03376113 {unpublished data only}
-
- NCT03376113. The effect of a brief psychological intervention on reducing self-harm repetition: feasibility study. clinicaltrials.gov/ct2/show/NCT03376113 (first received 18 December 2017).
NCT03489382 {unpublished data only}
-
- NCT03489382. The BEACON Study: protocol for cluster RCT of a service to deliver smartphone-assisted problem-solving therapy compared to usual care in men who present with intentional self-harm to the ED in Ontario (protocol A). clinicaltrials.gov/ct2/show/NCT03489382 (first received 5 April 2018).
NCT03533075 {unpublished data only}
-
- NCT03533075. A pilot effectiveness trial of the Teachable Moment Brief Intervention (TMBI) for veterans hospitalized following a suicide attempt. clinicaltrials.gov/ct2/show/NCT03533075 (first received 22 May 2018).
NCT03600532 {unpublished data only}
-
- NCT03600532. Testing the efficacy of the Teachable Moment Brief Intervention for suicide attempt survivors in an inpatient setting: effects on psychosocial and experimental pain outcomes. clinicaltrials.gov/ct2/show/NCT03600532 (first received 26 July 2018).
NCT03943862 {unpublished data only}
-
- NCT03943862. To Share or not to Share (2Share): group intervention to support disclosure decisions after suicide attempt. clinicaltrials.gov/ct2/show/NCT03943862 (first received 9 May 2019).
O'Toole 2019 {published data only}
-
- O'Toole MS, Arendt MB, Pedersen CM. Testing an app-assisted treatment for suicide prevention in a randomized controlled trial: effect on suicide risk and depression. Behavior Therapy 2019;50:421-9. - PubMed
Pearce 2017 {published data only}
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- Pearce S, Scott L, Attwood G, Saunders K, Dean M, De Ridder R, et al. Democratic therapeutic community treatment for personality disorder: randomised controlled trial. British Journal of Psychiatry 2017;210:149-56. - PubMed
Pfeiffer 2019 {published data only}
Philips 2018 {published data only}ISRCTN98982683
Pistorello 2020 {published data only}
-
- Pistorello J, Jobes DA, Gallop R, Compton SN, Locey NS, Au JS, et al. A randomized controlled trial of the Collaborative Assessment and Management of Suicidality (CAMS) versus Treatment As Usual (TAU) for suicidal college students. Archives of Suicide Research 2020 [ePub ahead of print]. [DOI: 10.1080/13811118.2020.1749742] - DOI - PMC - PubMed
Pratt 2015 {published data only}
Rees 2015 {published data only}
Rompogren 2018 {published data only}
-
- Rompogren JR. Using Resonance Frequency Breathing to Improve Distress Tolerance in Females who Engage in Non-Suicidal Self-Injury [Doctor of Philosophy thesis]. San Diego, CA: Alliant International University, 2018.
Rudd 2015 {published data only}
-
- Bryan CJ, Peterson AL, Rudd MD. Differential effects of brief CBT versus treatment as usual on posttreatment suicide attempts among groups of suicidal patients. Psychiatric Services 2018;69:703-9. - PubMed
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- Bryan CJ, Rudd MD, Peterson AL, Young-McCaughan S, Wertenberger EG. The ebb and flow of the wish to live and the wish to die among suicidal military personnel. Journal of Affective Disorders 2016;202:58-66. - PubMed
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- Bryan CJ, Wood DS, May A, Peterson AL, Wertenberger E, Rudd MD. 2017. Mechanisms of action contributing to reductions in suicide attempts following brief cognitive behavioral therapy for military personnel: a test of the interpersonal-psychological theory of suicide 2017;22:241-53. - PubMed
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- Rudd MD, Bryan CJ, Wertenberger EG, Peterson AL, Young-McCaughan S, Mintz J, et al. Brief cognitive-behavioral therapy effects on post-treatment suicide attempts in a military sample: results of a randomized clinical trial with 2-year follow-up. American Journal of Psychiatry 2015;172:441-9. - PubMed
Ryberg 2019 {published data only}
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- Ryberg W, Zahl P-H, Diep LM, Landrø NI, Fosse R. Managing suicidality within specialized care: a randomized controlled trial. Journal of Affective Disorders 2019;249:112-20. - PubMed
Sáiz 2014 {published and unpublished data}
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- Sáiz PA, Rodriguez-Revulta J, González-Blanco L, Burón P, Al-Halabi S, Garrido M, et al. Study protocol of a prevention of recurrent suicidal behavior program based on case management (PSyMAC). Revista de Psiquiatría y Salud Mental 2014;7:131-8. - PubMed
Santel 2020 {published data only}
-
- Santel M, Beblo T, Neuner F, Berg M, Hennig-Fast K, Jobes DA, et al. Collaborative Assessment and Management of Suicidality (CAMS) compared to Enhanced Treatment As Usual (E-TAU) for suicidal patients in an inpatient setting: study protocol for a randomized controlled trial. BMC Psychiatry 2020;20:183. - PMC - PubMed
Sayal 2019 {published and unpublished data}
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References to studies awaiting assessment
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NCT00834834 {unpublished data only}
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References to ongoing studies
ACTRN12617000529347 {unpublished data only}
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NCT03185026 {unpublished data only}
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NCT03427190 {unpublished data only}
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NCT03463980 {unpublished data only}
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NCT03541824 {unpublished data only}
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NCT03732300 {unpublished data only}
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NCT03853382 {unpublished data only}
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- NCT03853382. Cognitive Analytic Therapy-informed Containment for self-Harm (CATCH). clinicaltrials.gov/ct2/show/NCT03853382 (first received 25 February 2019).
NCT03894462 {unpublished data only}
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- NCT03894462. Effectiveness of a targeted brief intervention for recent suicide attempt survivors. clinicaltrials.gov/ct2/show/NCT03894462 (first received 28 March 2019).
NCT04072666 {unpublished data only}
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- NCT04072666. Investigations of psychological interventions in suicide prevention: a comparison of brief cognitive behavioural therapy and the attempted suicide short intervention program. clinicaltrials.gov/ct2/show/NCT04072666 (first received 28 August 2019).
NCT04168645 {unpublished data only}
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- NCT04168645. Inpatient cognitive-behavioral therapy to reduce suicide risk post-discharge. clinicaltrials.gov/ct2/show/NCT04168645 (first received 19 November 2019).
NCT04191122 {unpublished data only}
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- NCT04191122. Community Outpatient Psychotherapy Engagement Service for Self-harm (COPESS): a feasibility study. clinicaltrials.gov/ct2/show/NCT04191122 (first received 9 December 2019).
NCT04244786 {unpublished data only}
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- NCT04244786. Treating self injurious behavior: a novel brain stimulation approach. clinicaltrials.gov/ct2/show/NCT04244786 (first received 28 January 2020).
NCT04284085 {unpublished data only}
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- NCT04284085. Evaluation of a psychoeducational intervention for people with suicidal behaviour in the penitentiary environment: N'VIU project. clinicaltrials.gov/ct2/show/NCT04284085 (first received 25 February 2020).
NCT04343703 {unpublished data only}
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- NCT04343703. Suicide prevention and intervention (SURVIVE): cohort study and nested randomized controlled trials of secondary prevention programs for suicide attempts. clinicaltrials.gov/ct2/show/NCT04343703 (first received 13 April 2020).
NCT04366466 {published data only (unpublished sought but not used)}
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- NCT04366466. Program to Promote Engagement in care for the Prevention of Suicide recidivism (PEPS). clinicaltrials.gov/ct2/show/NCT04366466 (first received 29 April 2020).
NCT04420546 {unpublished data only}
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O'Connor 2019 {published data only}ISRCTN62181241
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- SLCTR/2017/008. A brief intervention for prevention of repetition of self-harm, among those who have recently attempted self-poisoning: a randomized controlled trial. slctr.lk/trials/slctr-2017-008 (first received 23 March 2017).
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