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. 2019 Dec 6:2019:8080564.
doi: 10.1155/2019/8080564. eCollection 2019.

Effects of Selenium and Melatonin on Ocular Ischemic Syndrome

Hande Hüsniye Telek  1
Affiliations

Effects of Selenium and Melatonin on Ocular Ischemic Syndrome

Hande Hüsniye Telek. Biomed Res Int. .

Abstract

Purpose: To determine the effects of selenium, melatonin, and selenium + melatonin administered for one month on anterior chamber (AC) malondialdehyde (MDA) and AC glutathione (GSH) levels in patients with ocular ischemic syndrome.

Materials and methods: Thirty-five patients were included in the study. Study groups were formed as follows: (1) control group, (2) ischemia group, (3) selenium + ischemia group, (4) melatonin + ischemia group, and (5) selenium + melatonin + ischemia group. AC samples were obtained. MDA and GSH levels in AC samples were evaluated.

Results: MDA levels were significantly increased in ischemia groups. Selenium and melatonin supplementation resulted in reduction of MDA levels and significant increase in GSH values.

Discussion: Increased lipid peroxidation associated with ischemia of the anterior segment has been prevented by selenium and melatonin supplementation. This trial is registered with ClinicalTrials.gov NCT04005222.

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Conflict of interest statement

The author declares that there are no conflicts of interest to declare.

References

    1. Gavrilenko A. V., Kuklin A. V., Kiseleva T. N. Efficacy of carotid endarterectomy in patients with stenosis of carotid arteries and acute vision impairment. Angiologia Sosudistaia Khirurgia. 2013;19(1):106–112. - PubMed
    1. Knox D. L. Ocular aspects of cervical vascular disease. Survey of Ophthalmology. 1969;13(5):245–262. - PubMed
    1. Karacostas D., Terzidou C., Voutas S., Rafou J., Artemis N., Georgiadis N. Isolated ocular ischemic syndrome with no cerebral involvement in common carotid artery occlusion. European Journal of Ophthalmology. 2001;11(1):97–101. doi: 10.1177/112067210101100121. - DOI - PubMed
    1. Ayada C., Toru Ü., Genç O., Akcılar R., Şahin S. Balanced oxidative status by nesfatin-1 in intestinal ischemia-reperfusion. International Journal of Clinical and Experimental Medicine. 2015;8:3318–3324. - PMC - PubMed
    1. Granger D. N., Kvietys P. R. Reperfusion injury and reactive oxygen species: the evolution of a concept. Redox Biology. 2015;6:524–551. doi: 10.1016/j.redox.2015.08.020. - DOI - PMC - PubMed

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