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Factors in the Initial Resuscitation of Patients With Severe Trauma: The FiiRST-2 Randomized Clinical Trial.
da Luz LT, Karkouti K, Carroll J, Grewal D, Jones M, Altmann J, Lin Y, Gupta A, Nathens AB, Kron A, Notario L, Beckett A, Petrosoniak A, Pavenski K, Vogt K, Ball IM, Parry NG, Engels PT, Zeller MP, Arnold DM, Belley-Côté E, Evans C, Leitch J, Shih A, Dawe PJ, Gooch R, Callum J. da Luz LT, et al. JAMA Netw Open. 2025 Sep 2;8(9):e2532702. doi: 10.1001/jamanetworkopen.2025.32702. JAMA Netw Open. 2025. PMID: 40982282 Free PMC article. Clinical Trial.
Protocol for a multicentre, randomised, parallel-control, superiority trial comparing administration of clotting factor concentrates with a standard massive haemorrhage protocol in severely bleeding trauma patients: the FiiRST 2 trial (a 2020 EAST multicentre trial).
da Luz LT, Callum J, Beckett A, Hucke HP, Carroll J, Grewal D, Schwartz B, Peng H, Engels PT, Parry N, Petrosoniak A, Tien H, Nathens AB, Scales D, Karkouti K. da Luz LT, et al. BMJ Open. 2021 Sep 3;11(9):e051003. doi: 10.1136/bmjopen-2021-051003. BMJ Open. 2021. PMID: 34479938 Free PMC article.