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Page 1
Showing results for nogo b
Search for Nago B instead (3 results)
Downregulation of Nogo-B ameliorates cerebral ischemia/reperfusion injury in mice through regulating microglia polarization via TLR4/NF-kappaB pathway.
Gong P, Jia HY, Li R, Ma Z, Si M, Qian C, Zhu FQ, Sheng-Yong L. Gong P, et al. Neurochem Int. 2023 Jul;167:105553. doi: 10.1016/j.neuint.2023.105553. Epub 2023 May 23. Neurochem Int. 2023. PMID: 37230196 Review.
Many studies have shown a close association between Nogo-B and inflammation-related diseases. However, uncertainty does exist, regarding Nogo-B function in the pathological progression of cerebral ischemia/reperfusion (I/R) injury. ...Nogo-B
Many studies have shown a close association between Nogo-B and inflammation-related diseases. However, uncertainty does exist, …
Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia.
Xue C, Zeng P, Gong K, Li Q, Feng Z, Wang M, Chen S, Yang Y, Li J, Zhang S, Yin Z, Liang Y, Yan T, Yu M, Feng K, Zhao D, Yang X, Zhang X, Ma L, Iwakiri Y, Chen L, Tang X, Chen Y, Chen H, Duan Y. Xue C, et al. Cell Rep. 2024 Sep 24;43(9):114691. doi: 10.1016/j.celrep.2024.114691. Epub 2024 Sep 3. Cell Rep. 2024. PMID: 39235944 Free article.
We discover that Nogo-B interacts with liver X receptor alpha (LXRalpha), and Nogo-B deficiency inhibits ubiquitination degradation of LXRalpha, thereby enhancing its function on cholesterol excretion. Decreased cellular cholesterol levels further acti …
We discover that Nogo-B interacts with liver X receptor alpha (LXRalpha), and Nogo-B deficiency inhibits ubiquit …
Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.
Zhang Y, Li JJ, Xu R, Wang XP, Zhao XY, Fang Y, Chen YP, Ma S, Di XH, Wu W, She G, Pang ZD, Wang YD, Zhang X, Xie W, Deng XL, Du XJ, Zhang Y. Zhang Y, et al. Redox Biol. 2023 Dec;68:102944. doi: 10.1016/j.redox.2023.102944. Epub 2023 Oct 21. Redox Biol. 2023. PMID: 37890359 Free PMC article.
We previously showed endothelial Nogo-B as a key regulator of endothelial function in the setting of hypertension. Here, we aim to further assess the role of Nogo-B in coronary atherosclerosis in ApoE(-/-) mice with pressure overload. ...Nogo- …
We previously showed endothelial Nogo-B as a key regulator of endothelial function in the setting of hypertension. Here, we ai …
Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage.
Gong K, Xue C, Feng Z, Pan R, Wang M, Chen S, Chen Y, Guan Y, Dai L, Zhang S, Jiang L, Li L, Wang B, Yin Z, Ma L, Iwakiri Y, Tang J, Liao C, Chen H, Duan Y. Gong K, et al. Nat Commun. 2024 Aug 10;15(1):6845. doi: 10.1038/s41467-024-51352-3. Nat Commun. 2024. PMID: 39122737 Free PMC article.
Intestinal Nogo-B knockout in male type 2 diabetes mellitus (T2DM) mice increases GLP1 and insulin levels and decreases glucagon levels, thereby alleviating pancreatic injury and insulin resistance. Finally, we identify aberrantly elevated Nogo-B expre …
Intestinal Nogo-B knockout in male type 2 diabetes mellitus (T2DM) mice increases GLP1 and insulin levels and decreases glucag …
Nogo-B receptor in relevant carcinoma: Current achievements, challenges and aims (Review).
Li YK, Xie YJ, Wu DC, Long SL, Tang S, Mo ZC. Li YK, et al. Int J Oncol. 2018 Nov;53(5):1827-1835. doi: 10.3892/ijo.2018.4520. Epub 2018 Aug 9. Int J Oncol. 2018. PMID: 30106141 Review.
The novel neurite outgrowth inhibitor B (Nogo-B) receptor (NgBR) is specific for Nogo-B, which is highly expressed in various human organs and cells, including the lung, liver, kidney, smooth muscle cells, blood vessel endothelial cells and infl …
The novel neurite outgrowth inhibitor B (Nogo-B) receptor (NgBR) is specific for Nogo-B, which is highly …
Nogo-B deficiency suppresses white adipogenesis by regulating beta-catenin signaling.
Li J, Sun Y, Xue C, Yang X, Duan Y, Zhao D, Han J. Li J, et al. Life Sci. 2023 May 15;321:121571. doi: 10.1016/j.lfs.2023.121571. Epub 2023 Mar 15. Life Sci. 2023. PMID: 36931495
AIMS: Obesity is a global epidemic around the world. Reticulon-4B (Nogo-B) is an endoplasmic reticulum-resident protein. Our previous work demonstrated that Nogo-B deficiency inhibited obesity and decreased the size of white adipocytes. ...In addition, …
AIMS: Obesity is a global epidemic around the world. Reticulon-4B (Nogo-B) is an endoplasmic reticulum-resident protein. Our p …
Nogo-B Promotes Endoplasmic Reticulum Stress-Mediated Autophagy in Endothelial Cells of Diabetic Nephropathy.
Zhang Y, Liu P, Yang S, Lan J, Xu H, Jiang H, Li J, Zhang T, Zhang H, Duan W, Gnudi L, Bai X. Zhang Y, et al. Antioxid Redox Signal. 2024 Oct;41(10-12):706-722. doi: 10.1089/ars.2023.0490. Epub 2024 Apr 12. Antioxid Redox Signal. 2024. PMID: 38497748
Yet, the role of Nogo-B in the regulation of ER stress and endothelial cell injury remains largely unknown. Herein, we tested the hypothesis that Nogo-B activates ER stress-mediated autophagy and protects endothelial cells in DN. Results: The level of …
Yet, the role of Nogo-B in the regulation of ER stress and endothelial cell injury remains largely unknown. Herein, we tested …
Nogo-B inhibition restricts ulcerative colitis via inhibiting p68/miR-155 signaling pathway.
Zheng J, Wang S, Zhang T, Li H, Zhu M, Wei X, Ge Y, Yang X, Zhang S, Xu H, Duan Y, Liu L, Chen Y. Zheng J, et al. Int Immunopharmacol. 2023 Jul;120:110378. doi: 10.1016/j.intimp.2023.110378. Epub 2023 May 25. Int Immunopharmacol. 2023. PMID: 37244119
Furthermore, we identified that Nogo-B inhibition can reduce the maturation of miR-155, which is essential for Nogo-B-affected inflammatory cytokines expression. Interestingly, we determined that Nogo-B and p68 can interact with each othe …
Furthermore, we identified that Nogo-B inhibition can reduce the maturation of miR-155, which is essential for Nogo- …
Secretory Nogo-B regulates Th2 differentiation in the lung cancer microenvironment.
Qin C, Li W, Zhang Y, Wang Z, Leng Y, Ma J, Qin C, Cheng S, Xue L, Song K, Huang B. Qin C, et al. Int Immunopharmacol. 2024 Oct 25;140:112763. doi: 10.1016/j.intimp.2024.112763. Epub 2024 Jul 30. Int Immunopharmacol. 2024. PMID: 39083925
In this study, we demonstrate that Nogo-B expression and secretion are upregulated in lung cancer and correlate to overall survival. Nogo-B is secreted by various cells, particularly lung cancer cells. ER stress and phosphorylation at serine 107 can in …
In this study, we demonstrate that Nogo-B expression and secretion are upregulated in lung cancer and correlate to overall sur …
Macrophage Nogo-B Drives Liver Fibrosis.
Zhang L, Ni M, Si J, Cheng F, Zhang L, Liang Y, Liu M, Li W, Li J, Chi Y, Rao J, Lu L. Zhang L, et al. Cell Mol Gastroenterol Hepatol. 2025 Sep 2:101622. doi: 10.1016/j.jcmgh.2025.101622. Online ahead of print. Cell Mol Gastroenterol Hepatol. 2025. PMID: 40907664 Free article.
As an endoplasmic reticulum-residential protein, Nogo-B strongly regulates macrophage function, but whether Nogo-B-decorated macrophages affect inflammation and progression during liver fibrosis is unclear. ...By utilizing myeloid-specific Nogo- …
As an endoplasmic reticulum-residential protein, Nogo-B strongly regulates macrophage function, but whether Nogo-B
1,008 results