Randomized Controlled Trial

. 2019 Mar 28;380(13):1214-1225.

doi: 10.1056/NEJMoa1816476. Epub 2019 Mar 19.

Volatile Anesthetics versus Total Intravenous Anesthesia for Cardiac Surgery

Giovanni Landoni¹, Vladimir V Lomivorotov¹, Caetano Nigro Neto¹, Fabrizio Monaco¹, Vadim V Pasyuga¹, Nikola Bradic¹, Rosalba Lembo¹, Gordana Gazivoda¹, Valery V Likhvantsev¹, Chong Lei¹, Andrey Lozovskiy¹, Nora Di Tomasso¹, Nazar A R Bukamal¹, Fernanda S Silva¹, Andrey E Bautin¹, Jun Ma¹, Martina Crivellari¹, Ahmed M G A Farag¹, Nikolay S Uvaliev¹, Cristiana Carollo¹, Marina Pieri¹, Jan Kunstýř¹, Chew Yin Wang¹, Alessandro Belletti¹, Ludhmila A Hajjar¹, Evgeny V Grigoryev¹, Felice E Agrò¹, Hynek Riha¹, Mohamed R El-Tahan¹, A Mara Scandroglio¹, Abeer M Elnakera¹, Massimo Baiocchi¹, Paolo Navalesi¹, Vladimir A Shmyrev¹, Luca Severi¹, Mohammed A Hegazy¹, Giuseppe Crescenzi¹, Dmitry N Ponomarev¹, Luca Brazzi¹, Renato Arnoni¹, Dmitry G Tarasov¹, Miomir Jovic¹, Maria G Calabrò¹, Tiziana Bove¹, Rinaldo Bellomo¹, Alberto Zangrillo¹; MYRIAD Study Group

Collaborators, Affiliations

Collaborators

MYRIAD Study Group:
Rinaldo Bellomo, Colin F Royse, Nazar A R Bukamal, Angel V Espinosa, Shreeram K Sabade, Renato Arnoni, Francisco J L Bezerra, Vinicius T N S Nascimento, Caetano Nigro Neto, Ligia Camara, Filomena R B G Galas, Ludhmila A Hajjar, Dimitar G Dimitrov, Irina V Dovalyovska, Nikolay S Uvaliev, Hui Chi, Jun Ma, Chengbin Wang, Zhijian Li, Junmei Xu, Hailong Dong, Lihong Hou, Chong Lei, Yuhua Cheng, Weiqin Huang, Nikola Bradic, Jan Kunstýř, Hynek Riha, Mohammed A Hegazy, Hani I Taman, Abeer M Elnakera, Marco Adversi, Massimo Baiocchi, Maria Silvia Ravaglia, Mario Frontini, Gabriele Alvaro, Alessandro D'Amico, Ovidia Lavalle, Emanuela Saporito, Paolo Navalesi, Giovani Affronti, Silvia Ajello, Martina Baiardo Redaelli, Alessandro Belletti, Luca Cabrini, Maria Grazia Calabrò, Martina Crivellari, Giuseppe Dalessandro, Monica De Luca, Ambra Ambra, L Di Prima, Nora Di Tomasso, Greta Fano, Annalisa Franco, Samuele Frassoni, Giovanna Frau, Chiara Gerli, Giuseppe Giardina, Giovanni Landoni, Rosalba Lembo, Margherita Licheri, Giulio Melisurgo, Fabrizio Monaco, Giacomo Monti, Marta Mucchetti, Pasquale Nardelli, Alessandro Oriani, Federico Pappalardo, Marina Pieri, Chiara Sartini, Anna Mara Scandroglio, Carmine D Votta, Alberto Zangrillo, Antonio Pisano, Cristiana Carollo, Demetrio Pittarello, Gianluca Paternoster, Luca Severi, Felice E Agrò, Domenico Sarubbi, Giuseppe Crescenzi, Graziano Cortis, Licia C M Melis, Francesco Greco, Maria Luisa Contristano, Luca Brazzi, Salvatore Di Blasi, Tiziana Bove, Marida Luraschi, Zuraini Md Noor, Siti Nurhidayah Rahim, Hanafi Sidik, Norzalina Esa, Marzida Mansor, Chew Yin Wang, Chow Yen Yong, Cheeliat Tang, Catarina A Barreiros, Ana P Ferro, Fernanda S Silva, Sergey I Belov, Sergey A Berezhnoi, Igor L Nudel, Vadim V Pasyuga, Dmitry G Tarasov, Eleonora S Yusupova, Aleksandra Raskatova, Nikolay Shadrin, Andrey Lozovskiy, Dmitriy L Shukevich, Evgeny V Grigoryev, Oleg N Gerasimenko, Valery V Likhvantsev, Alexey M Ovezov, Olga N Ulitkina, Marat N Abubakirov, Vladimir V Lomivorotov, Dmitry N Ponomarev, Vladimir A Shmyrev, Nikita A Tarkunov, Pavel E Vedernikov, Andrey E Bautin, Evgeny A Homenko, Ludmila I Karpova, Mohamed R El-Tahan, Mohammed N A Abdelatti, Mohammed A Mourad, Ahmed M G A Farag, Gordana Gazivoda, Nikola Joksic, Miomir Jovic, Jelena Lesanovic, Vladimir Savic, Dragana Unic-Stojanovic, Jun Hyun Kim, Gudrun Kunst

Affiliation

¹ From the Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute (G.L., F.M., R.L., N.D.T., M.C., M.P., A.B., A.M.S., M.G.C., A.Z.), and Vita-Salute San Raffaele University (G.L., A.Z.), Milan, Istituto di Anestesia e Rianimazione, Azienda Ospedaliera di Padova, Padua (C.C.), Anesthesia and Intensive Care Department, University Campus Bio-Medico of Rome (F.E.A.), and Anestesia e Rianimazione, Dipartimento Cardiovascolare, Azienda Ospedaliera San Camillo Forlanini (L.S.), Rome, the Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, University Hospital Policlinico S. Orsola, Bologna (M.B.), Dipartimento di Scienze Mediche e Chirurgiche, Università Magna Graecia di Catanzaro, Catanzaro (P.N.), Anestesia e Terapia Intensiva Cardiochirurgica, Istituto Clinico Humanitas, Rozzano (G.C.), the Department of Anesthesia, Intensive Care and Emergency, Città della Salute e della Scienza Hospital, and the Department of Surgical Sciences, University of Turin, Turin (L.B.), and the Anesthesiology and Intensive Care Clinic, Department of Medicine, University of Udine, Udine (T.B.) - all in Italy; the Department of Anesthesiology and Intensive Care, E. Meshalkin National Medical Research Center, Novosibirsk (V.V. Lomivorotov, V.A.S., D.N.P.), the Departments of Anesthesiology and Intensive Care (V.V.P.) and Cardiac Surgery (D.G.T.), Federal Center for Cardiovascular Surgery Astrakhan, Astrakhan, the Department of Anesthesia and Intensive Care, First Moscow State Medical University (V.V.P., V.V. Likhvantsev), and the Department of Intensive Care, Moscow Regional Clinical and Research Institute (V.V. Likhvantsev), Moscow, the Department of Anesthesia and Intensive Care, Ural Institute of Cardiology, Ekaterinburg (A.L.), the Laboratory for Anesthesiology and Intensive Care, Almazov National Medical Research Center, Saint Petersburg (A.E.B.), and the Intensive Care Unit, Scientific Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo (E.V.G.) - all in Russia; the Anesthesia Section, Department of Surgery, Dante Pazzanese Institute of Cardiology (C.N.N.), the Department of Cardiopneumology, Instituto do Coração, Universidade de São Paulo, and the Intensive Care Unit, Hospital SirioLibanes (L.A.H.), and the Cardiac Surgery Section, Department of Surgery, Dante Pazzanese Institute of Cardiology (R.A.), São Paulo, Brazil; the Department of Cardiovascular Anesthesiology and Intensive Care Medicine, and the Clinical Department of Anesthesiology, Resuscitation and Intensive Care Medicine, University Hospital Dubrava, Zagreb (N.B.), and the Department of Biomedical Sciences, University North, Varaždin (N.B.) - both in Croatia; the Department of Anesthesia and Intensive Care, Cardiovascular Institute Dedinje (G.G., M.J.), and the School of Medicine, University of Belgrade (M.J.), Belgrade, Serbia; the Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi (C.L.), and the Center for Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing (J.M.) - both in China; the Cardiothoracic Intensive Care Unit and Anesthesia Department, Mohammed Bin Khalifa Cardiac Center, Riffa, Bahrain (N.A.R.B.); the Department of Anesthesiology, Hospital de Santa Maria, Lisbon, Portugal (F.S.S.); the Department of Anesthesia, King Abdullah Medical City-Holy Capital, Makkah (A.M.G.A.F.), and the Anesthesiology Department, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam (M.R.E.-T.) - both in Saudi Arabia; Anesthesia and Intensive Care, Acibadem City Clinic-Cardiac Surgery Center, Burgas, Bulgaria (N.S.U.); the Department of Anesthesiology, Resuscitation and Intensive Medicine, Charles University in Prague, First Faculty of Medicine and General Teaching Hospital (J.K.), and the Cardiothoracic Anesthesiology and Intensive Care, Department of Anesthesiology and Intensive Care Medicine, Institute for Clinical and Experimental Medicine (H.R.), Prague, Czech Republic; the Department of Anesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia (C.Y.W.); the Anesthesia and Surgical Intensive Care Department, Faculty of Medicine, Zagazig University Hospitals, Zagazig (A.M.E.), and the Department of Anesthesia and Surgical Intensive Care, Mansoura University, Mansoura (M.A.H.) - both in Egypt; and the School of Medicine, University of Melbourne, Melbourne, VIC, Australia (R.B.).

PMID: 30888743
DOI: 10.1056/NEJMoa1816476

Free article

Randomized Controlled Trial

Volatile Anesthetics versus Total Intravenous Anesthesia for Cardiac Surgery

Giovanni Landoni et al. N Engl J Med. 2019.

Free article

. 2019 Mar 28;380(13):1214-1225.

doi: 10.1056/NEJMoa1816476. Epub 2019 Mar 19.

Authors

Collaborators

MYRIAD Study Group:
Rinaldo Bellomo, Colin F Royse, Nazar A R Bukamal, Angel V Espinosa, Shreeram K Sabade, Renato Arnoni, Francisco J L Bezerra, Vinicius T N S Nascimento, Caetano Nigro Neto, Ligia Camara, Filomena R B G Galas, Ludhmila A Hajjar, Dimitar G Dimitrov, Irina V Dovalyovska, Nikolay S Uvaliev, Hui Chi, Jun Ma, Chengbin Wang, Zhijian Li, Junmei Xu, Hailong Dong, Lihong Hou, Chong Lei, Yuhua Cheng, Weiqin Huang, Nikola Bradic, Jan Kunstýř, Hynek Riha, Mohammed A Hegazy, Hani I Taman, Abeer M Elnakera, Marco Adversi, Massimo Baiocchi, Maria Silvia Ravaglia, Mario Frontini, Gabriele Alvaro, Alessandro D'Amico, Ovidia Lavalle, Emanuela Saporito, Paolo Navalesi, Giovani Affronti, Silvia Ajello, Martina Baiardo Redaelli, Alessandro Belletti, Luca Cabrini, Maria Grazia Calabrò, Martina Crivellari, Giuseppe Dalessandro, Monica De Luca, Ambra Ambra, L Di Prima, Nora Di Tomasso, Greta Fano, Annalisa Franco, Samuele Frassoni, Giovanna Frau, Chiara Gerli, Giuseppe Giardina, Giovanni Landoni, Rosalba Lembo, Margherita Licheri, Giulio Melisurgo, Fabrizio Monaco, Giacomo Monti, Marta Mucchetti, Pasquale Nardelli, Alessandro Oriani, Federico Pappalardo, Marina Pieri, Chiara Sartini, Anna Mara Scandroglio, Carmine D Votta, Alberto Zangrillo, Antonio Pisano, Cristiana Carollo, Demetrio Pittarello, Gianluca Paternoster, Luca Severi, Felice E Agrò, Domenico Sarubbi, Giuseppe Crescenzi, Graziano Cortis, Licia C M Melis, Francesco Greco, Maria Luisa Contristano, Luca Brazzi, Salvatore Di Blasi, Tiziana Bove, Marida Luraschi, Zuraini Md Noor, Siti Nurhidayah Rahim, Hanafi Sidik, Norzalina Esa, Marzida Mansor, Chew Yin Wang, Chow Yen Yong, Cheeliat Tang, Catarina A Barreiros, Ana P Ferro, Fernanda S Silva, Sergey I Belov, Sergey A Berezhnoi, Igor L Nudel, Vadim V Pasyuga, Dmitry G Tarasov, Eleonora S Yusupova, Aleksandra Raskatova, Nikolay Shadrin, Andrey Lozovskiy, Dmitriy L Shukevich, Evgeny V Grigoryev, Oleg N Gerasimenko, Valery V Likhvantsev, Alexey M Ovezov, Olga N Ulitkina, Marat N Abubakirov, Vladimir V Lomivorotov, Dmitry N Ponomarev, Vladimir A Shmyrev, Nikita A Tarkunov, Pavel E Vedernikov, Andrey E Bautin, Evgeny A Homenko, Ludmila I Karpova, Mohamed R El-Tahan, Mohammed N A Abdelatti, Mohammed A Mourad, Ahmed M G A Farag, Gordana Gazivoda, Nikola Joksic, Miomir Jovic, Jelena Lesanovic, Vladimir Savic, Dragana Unic-Stojanovic, Jun Hyun Kim, Gudrun Kunst

Affiliation

¹ From the Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute (G.L., F.M., R.L., N.D.T., M.C., M.P., A.B., A.M.S., M.G.C., A.Z.), and Vita-Salute San Raffaele University (G.L., A.Z.), Milan, Istituto di Anestesia e Rianimazione, Azienda Ospedaliera di Padova, Padua (C.C.), Anesthesia and Intensive Care Department, University Campus Bio-Medico of Rome (F.E.A.), and Anestesia e Rianimazione, Dipartimento Cardiovascolare, Azienda Ospedaliera San Camillo Forlanini (L.S.), Rome, the Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, University Hospital Policlinico S. Orsola, Bologna (M.B.), Dipartimento di Scienze Mediche e Chirurgiche, Università Magna Graecia di Catanzaro, Catanzaro (P.N.), Anestesia e Terapia Intensiva Cardiochirurgica, Istituto Clinico Humanitas, Rozzano (G.C.), the Department of Anesthesia, Intensive Care and Emergency, Città della Salute e della Scienza Hospital, and the Department of Surgical Sciences, University of Turin, Turin (L.B.), and the Anesthesiology and Intensive Care Clinic, Department of Medicine, University of Udine, Udine (T.B.) - all in Italy; the Department of Anesthesiology and Intensive Care, E. Meshalkin National Medical Research Center, Novosibirsk (V.V. Lomivorotov, V.A.S., D.N.P.), the Departments of Anesthesiology and Intensive Care (V.V.P.) and Cardiac Surgery (D.G.T.), Federal Center for Cardiovascular Surgery Astrakhan, Astrakhan, the Department of Anesthesia and Intensive Care, First Moscow State Medical University (V.V.P., V.V. Likhvantsev), and the Department of Intensive Care, Moscow Regional Clinical and Research Institute (V.V. Likhvantsev), Moscow, the Department of Anesthesia and Intensive Care, Ural Institute of Cardiology, Ekaterinburg (A.L.), the Laboratory for Anesthesiology and Intensive Care, Almazov National Medical Research Center, Saint Petersburg (A.E.B.), and the Intensive Care Unit, Scientific Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo (E.V.G.) - all in Russia; the Anesthesia Section, Department of Surgery, Dante Pazzanese Institute of Cardiology (C.N.N.), the Department of Cardiopneumology, Instituto do Coração, Universidade de São Paulo, and the Intensive Care Unit, Hospital SirioLibanes (L.A.H.), and the Cardiac Surgery Section, Department of Surgery, Dante Pazzanese Institute of Cardiology (R.A.), São Paulo, Brazil; the Department of Cardiovascular Anesthesiology and Intensive Care Medicine, and the Clinical Department of Anesthesiology, Resuscitation and Intensive Care Medicine, University Hospital Dubrava, Zagreb (N.B.), and the Department of Biomedical Sciences, University North, Varaždin (N.B.) - both in Croatia; the Department of Anesthesia and Intensive Care, Cardiovascular Institute Dedinje (G.G., M.J.), and the School of Medicine, University of Belgrade (M.J.), Belgrade, Serbia; the Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi (C.L.), and the Center for Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing (J.M.) - both in China; the Cardiothoracic Intensive Care Unit and Anesthesia Department, Mohammed Bin Khalifa Cardiac Center, Riffa, Bahrain (N.A.R.B.); the Department of Anesthesiology, Hospital de Santa Maria, Lisbon, Portugal (F.S.S.); the Department of Anesthesia, King Abdullah Medical City-Holy Capital, Makkah (A.M.G.A.F.), and the Anesthesiology Department, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam (M.R.E.-T.) - both in Saudi Arabia; Anesthesia and Intensive Care, Acibadem City Clinic-Cardiac Surgery Center, Burgas, Bulgaria (N.S.U.); the Department of Anesthesiology, Resuscitation and Intensive Medicine, Charles University in Prague, First Faculty of Medicine and General Teaching Hospital (J.K.), and the Cardiothoracic Anesthesiology and Intensive Care, Department of Anesthesiology and Intensive Care Medicine, Institute for Clinical and Experimental Medicine (H.R.), Prague, Czech Republic; the Department of Anesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia (C.Y.W.); the Anesthesia and Surgical Intensive Care Department, Faculty of Medicine, Zagazig University Hospitals, Zagazig (A.M.E.), and the Department of Anesthesia and Surgical Intensive Care, Mansoura University, Mansoura (M.A.H.) - both in Egypt; and the School of Medicine, University of Melbourne, Melbourne, VIC, Australia (R.B.).

PMID: 30888743
DOI: 10.1056/NEJMoa1816476

Abstract

Background: Volatile (inhaled) anesthetic agents have cardioprotective effects, which might improve clinical outcomes in patients undergoing coronary-artery bypass grafting (CABG).

Methods: We conducted a pragmatic, multicenter, single-blind, controlled trial at 36 centers in 13 countries. Patients scheduled to undergo elective CABG were randomly assigned to an intraoperative anesthetic regimen that included a volatile anesthetic (desflurane, isoflurane, or sevoflurane) or to total intravenous anesthesia. The primary outcome was death from any cause at 1 year.

Results: A total of 5400 patients were randomly assigned: 2709 to the volatile anesthetics group and 2691 to the total intravenous anesthesia group. On-pump CABG was performed in 64% of patients, with a mean duration of cardiopulmonary bypass of 79 minutes. The two groups were similar with respect to demographic and clinical characteristics at baseline, the duration of cardiopulmonary bypass, and the number of grafts. At the time of the second interim analysis, the data and safety monitoring board advised that the trial should be stopped for futility. No significant difference between the groups with respect to deaths from any cause was seen at 1 year (2.8% in the volatile anesthetics group and 3.0% in the total intravenous anesthesia group; relative risk, 0.94; 95% confidence interval [CI], 0.69 to 1.29; P = 0.71), with data available for 5353 patients (99.1%), or at 30 days (1.4% and 1.3%, respectively; relative risk, 1.11; 95% CI, 0.70 to 1.76), with data available for 5398 patients (99.9%). There were no significant differences between the groups in any of the secondary outcomes or in the incidence of prespecified adverse events, including myocardial infarction.

Conclusions: Among patients undergoing elective CABG, anesthesia with a volatile agent did not result in significantly fewer deaths at 1 year than total intravenous anesthesia. (Funded by the Italian Ministry of Health; MYRIAD ClinicalTrials.gov number, NCT02105610.).

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Comment in

Anesthesia for Cardiac Surgery.
Pal N, Nelson M, Butterworth J. Pal N, et al. N Engl J Med. 2019 Jul 4;381(1):96. doi: 10.1056/NEJMc1905784. N Engl J Med. 2019. PMID: 31269378 No abstract available.
Anesthesia for Cardiac Surgery.
Zaugg M, Clanachan AS, Lucchinetti E. Zaugg M, et al. N Engl J Med. 2019 Jul 4;381(1):96. doi: 10.1056/NEJMc1905784. N Engl J Med. 2019. PMID: 31269379 No abstract available.
Anesthesia for Cardiac Surgery.
Magunia H, Keller M, Rosenberger P. Magunia H, et al. N Engl J Med. 2019 Jul 4;381(1):96-97. doi: 10.1056/NEJMc1905784. N Engl J Med. 2019. PMID: 31269380 No abstract available.
Anesthesia for Cardiac Surgery.
Diaz Milian R. Diaz Milian R. N Engl J Med. 2019 Jul 4;381(1):97. doi: 10.1056/NEJMc1905784. N Engl J Med. 2019. PMID: 31269381 No abstract available.

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Volatile Anesthetics versus Total Intravenous Anesthesia for Cardiac Surgery

Collaborators

Affiliation

Volatile Anesthetics versus Total Intravenous Anesthesia for Cardiac Surgery

Authors

Collaborators

Affiliation

Abstract

Comment in

Publication types

MeSH terms

Substances

Associated data

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical