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Page 1
Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2.
Němec V, Remeš M, Beňovský P, Böck MC, Šranková E, Wong JF, Cros J, Williams E, Tse LH, Smil D, Ensan D, Isaac MB, Al-Awar R, Gomolková R, Ursachi VC, Fafílek B, Kahounová Z, Víchová R, Vacek O, Berger BT, Wells CI, Corona CR, Vasta JD, Robers MB, Krejci P, Souček K, Bullock AN, Knapp S, Paruch K. Němec V, et al. J Med Chem. 2024 Aug 8;67(15):12632-12659. doi: 10.1021/acs.jmedchem.4c00629. Epub 2024 Jul 18. J Med Chem. 2024. PMID: 39023313 Free PMC article.
Workflow for E3 Ligase Ligand Validation for PROTAC Development.
Miletić N, Weckesser J, Mosler T, Rathore R, Hoffmann ME, Gehrtz P, Schlesiger S, Hartung IV, Berner N, Wilhelm S, Müller J, Adhikari B, Němec V, Sivashanmugam SA, Elson L, Holzmann H, Schwalm MP, Hoffmann L, Abdul Azeez KR, Müller S, Kuster B, Wolf E, Đikić I, Knapp S. Miletić N, et al. Among authors: nemec v. ACS Chem Biol. 2025 Feb 21;20(2):507-521. doi: 10.1021/acschembio.4c00812. Epub 2025 Feb 11. ACS Chem Biol. 2025. PMID: 39932098 Free PMC article.
Development and Discovery of a Selective Degrader of Casein Kinases 1 δ/ε.
Haag A, Němec V, Janovská P, Bartošíková J, Adhikari B, Müller J, Schwalm MP, Čada Š, Ohmayer U, Daub H, Kim Y, Born F, Wolf E, Bryja V, Knapp S. Haag A, et al. Among authors: nemec v. J Med Chem. 2025 Jan 9;68(1):506-530. doi: 10.1021/acs.jmedchem.4c02201. Epub 2024 Dec 27. J Med Chem. 2025. PMID: 39729064
[Peutz-Jeghers syndrome].
Antonová J, Nĕmec V, Formánek P. Antonová J, et al. Among authors: nemec v. Rozhl Chir. 1999 Jul;78(7):347-50. Rozhl Chir. 1999. PMID: 10596571 Czech.
45 results