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Review
. 2011 Jul;12(4):387-92.
doi: 10.1097/PCC.0b013e3181fe4058.

The Collaborative Pediatric Critical Care Research Network Critical Pertussis Study: collaborative research in pediatric critical care medicine

Jeri S Burr  1 , Tammara L Jenkins, Rick Harrison, Kathleen Meert, K J S Anand, John T Berger, Jerry Zimmerman, Joseph Carcillo, J Michael Dean, Christopher J L Newth, Douglas F Willson, Ronald C Sanders Jr, Murray M Pollack, Eric Harvill, Carol E Nicholson; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN)
Collaborators, Affiliations
Review

The Collaborative Pediatric Critical Care Research Network Critical Pertussis Study: collaborative research in pediatric critical care medicine

Jeri S Burr et al. Pediatr Crit Care Med. 2011 Jul.

Abstract

Objective: To provide an updated overview of critical pertussis to the pediatric critical care community and describe a study of critical pertussis recently undertaken.

Setting: The six sites, seven hospitals of the Collaborative Pediatric Critical Care Research Network, and 17 outside sites at academic medical centers with pediatric intensive care units.

Results: Despite high coverage for childhood vaccination, pertussis causes substantial morbidity and mortality in US children, especially among infants. In pediatric intensive care units, Bordetella pertussis is a community-acquired pathogen associated with critical illness and death. The incidence of medical and developmental sequelae in critical pertussis survivors remains unknown, and the appropriate strategies for treatment and support remain unclear. The Collaborative Pediatric Critical Care Research Network Critical Pertussis Study has begun to evaluate critical pertussis in a prospective cohort.

Conclusion: Research is urgently needed to provide an evidence base that might optimize management for critical pertussis, a serious, disabling, and too often fatal illness for U.S. children and those in the developing world.

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Conflict of interest statement

Conflict of interest: All authors, no conflict reported

Disclaimer: The findings and conclusions in this manuscript are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.

Figures

Figure 1
Figure 1
Number of reported pertussis cases, by year – United States, 1922–2006 Source: For 1950–2006, CDC, National Notifiable Diseases Surveillance System; for 1922–1949, passive reports to the U.S. Public Health Service.(15)
See this image and copyright information in PMC

Comment in

References

    1. Mattoo S, Cherry JD. Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies. Clin Microbiol Rev. 2005;18(2):326–382. - PMC - PubMed
    1. Cherry JD. Defining Pertussis Epidemiology: Clinical, Microbiologic and Serologic Perspectives. The Pediatric Infectious Disease Journal. 2005;24(5):S25–S34. - PubMed
    1. Christie CD, Baltimore RS. Pertussis in neonates. Am J Dis Child. 1989;143(10):1199–1202. - PubMed
    1. Halperin SA. Pertussis--a disease and vaccine for all ages. N Engl J Med. 2005;353(15):1615–1617. - PubMed
    1. Halperin SA. The control of pertussis--2007 and beyond. N Engl J Med. 2007;356(2):110–113. - PubMed

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