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The effect of computerised decision support alerts tailored to intensive care on the administration of high-risk drug combinations, and their monitoring: a cluster randomised stepped-wedge trial.
Bakker T, Klopotowska JE, Dongelmans DA, Eslami S, Vermeijden WJ, Hendriks S, Ten Cate J, Karakus A, Purmer IM, van Bree SHW, Spronk PE, Hoeksema M, de Jonge E, de Keizer NF, Abu-Hanna A; SIMPLIFY study group. Bakker T, et al. Lancet. 2024 Feb 3;403(10425):439-449. doi: 10.1016/S0140-6736(23)02465-0. Epub 2024 Jan 20. Lancet. 2024. PMID: 38262430 Clinical Trial.
Effect of a Lower vs Higher Positive End-Expiratory Pressure Strategy on Ventilator-Free Days in ICU Patients Without ARDS: A Randomized Clinical Trial.
Writing Committee and Steering Committee for the RELAx Collaborative Group; Algera AG, Pisani L, Serpa Neto A, den Boer SS, Bosch FFH, Bruin K, Klooster PM, Van der Meer NJM, Nowitzky RO, Purmer IM, Slabbekoorn M, Spronk PE, van Vliet J, Weenink JJ, Gama de Abreu M, Pelosi P, Schultz MJ, Paulus F. Writing Committee and Steering Committee for the RELAx Collaborative Group, et al. Among authors: nowitzky ro. JAMA. 2020 Dec 22;324(24):2509-2520. doi: 10.1001/jama.2020.23517. JAMA. 2020. PMID: 33295981 Free PMC article. Clinical Trial.
Association of ventilation volumes, pressures and rates with the mechanical power of ventilation in patients without acute respiratory distress syndrome: exploring the impact of rate reduction.
Buiteman-Kruizinga LA, van Meenen DMP, Serpa Neto A, Mazzinari G, Bos LDJ, van der Heiden PLJ, Paulus F, Schultz MJ; NEBULAE; PReVENT; RELAx; investigators. Buiteman-Kruizinga LA, et al. Anaesthesia. 2025 May;80(5):533-542. doi: 10.1111/anae.16537. Epub 2025 Jan 13. Anaesthesia. 2025. PMID: 39938476 Free PMC article.