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Safety and efficacy of low-intensity versus standard monitoring following intravenous thrombolytic treatment in patients with acute ischaemic stroke (OPTIMISTmain): an international, pragmatic, stepped-wedge, cluster-randomised, controlled non-inferiority trial.
Anderson CS, Summers D, Ouyang M, Sui Y, Johnson B, Billot L, Malavera A, Faigle R, Muñoz-Venturelli P, Day D, Liu X, Li Q, Song L, Robinson TG, González F, Urrutia-Goldsack F, Iacobelli M, Montalbano M, Pruski A, Delcourt C, Durham AC, Ebraimo A, Van Ta HH, Ghosh P, Leonhardt-Caprio A, Nguyen HT, Ton MD, Jan S, Liu H, Lindley RI, Arauz A, Mercado A, Zaidi WAW, Khatri P, Wang X, Urrutia VC; OPTIMISTmain Investigators. Anderson CS, et al. Lancet. 2025 May 31;405(10493):1909-1922. doi: 10.1016/S0140-6736(25)00549-5. Epub 2025 May 21. Lancet. 2025. PMID: 40412428 Clinical Trial.
The main Optimal Post rTpa-Iv Monitoring in Ischemic Stroke Trial (OPTIMISTmain): Protocol for a Pragmatic, Stepped Wedge, Cluster Randomized Controlled Trial.
Ouyang M, Faigle R, Wang X, Johnson B, Summers D, Khatri P, Billot L, Liu H, Malavera A, Muñoz-Venturelli P, González F, Urrutia F, Day D, Song L, Sui Y, Delcourt C, Robinson T, Durham AC, Ebraimo A, Wan Zaidi WA, Jan S, Lindley RI, Urrutia VC, Anderson CS; OPTIMISTmain Investigators. Ouyang M, et al. Cerebrovasc Dis. 2024;53(5):635-642. doi: 10.1159/000534706. Epub 2023 Oct 26. Cerebrovasc Dis. 2024. PMID: 37883934 Free article.