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2,019 results

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Page 1
Showing results for offer ka
Search for Offei KA instead (1 results)
Hypertrophic Cardiomyopathy: An Overview of Genetics and Management.
Teekakirikul P, Zhu W, Huang HC, Fung E. Teekakirikul P, et al. Biomolecules. 2019 Dec 16;9(12):878. doi: 10.3390/biom9120878. Biomolecules. 2019. PMID: 31888115 Free PMC article. Review.
Important insights into the genetic landscape of HCM have enhanced our understanding of the molecular pathogenesis, empowered gene-based diagnostic testing to identify at-risk individuals, and offered potential targets for the development of therapeutic agents. This articl …
Important insights into the genetic landscape of HCM have enhanced our understanding of the molecular pathogenesis, empowered gene-based dia …
Setting and Titrating Positive End-Expiratory Pressure.
Millington SJ, Cardinal P, Brochard L. Millington SJ, et al. Chest. 2022 Jun;161(6):1566-1575. doi: 10.1016/j.chest.2022.01.052. Epub 2022 Feb 5. Chest. 2022. PMID: 35131298 Review.
Many busy clinicians use a "one-size-fits-all" approach based on local medical culture, but an individualized approach has the potential to offer significant benefit. Here we present a pragmatic approach based on simple measurements available on all ventilators, focused on …
Many busy clinicians use a "one-size-fits-all" approach based on local medical culture, but an individualized approach has the potential to …
The Kainic Acid Models of Temporal Lobe Epilepsy.
Rusina E, Bernard C, Williamson A. Rusina E, et al. eNeuro. 2021 Apr 9;8(2):ENEURO.0337-20.2021. doi: 10.1523/ENEURO.0337-20.2021. Print 2021 Mar-Apr. eNeuro. 2021. PMID: 33658312 Free PMC article. Review.
Experimental models of epilepsy are useful to identify potential mechanisms of epileptogenesis, seizure genesis, comorbidities, and treatment efficacy. The kainic acid (KA) model is one of the most commonly used. Several modes of administration of KA exist, each pro …
Experimental models of epilepsy are useful to identify potential mechanisms of epileptogenesis, seizure genesis, comorbidities, and treatmen …
How to Begin a Quality Improvement Project.
Silver SA, Harel Z, McQuillan R, Weizman AV, Thomas A, Chertow GM, Nesrallah G, Bell CM, Chan CT. Silver SA, et al. Clin J Am Soc Nephrol. 2016 May 6;11(5):893-900. doi: 10.2215/CJN.11491015. Epub 2016 Mar 25. Clin J Am Soc Nephrol. 2016. PMID: 27016497 Free PMC article.
Physician engagement is a particularly important component of project success, and the knowledge that patients/caregivers can offer as members of a quality improvement team should not be overlooked. After a team is formed, an improvement framework helps to organize the sci …
Physician engagement is a particularly important component of project success, and the knowledge that patients/caregivers can offer a …
Mapping the pancancer metastasis tumor microbiome.
Wong CC, Yu J. Wong CC, et al. Cell. 2024 Apr 25;187(9):2126-2128. doi: 10.1016/j.cell.2024.03.040. Cell. 2024. PMID: 38670070 Free article.
In this issue of Cell, Voest et al. profiled the tumor metastasis-associated microbiome in a pancancer cohort of 4,160 biopsies from 26 cancer types. This dataset offers a useful resource for understanding the role of the microbiome in metastatic cancers....
In this issue of Cell, Voest et al. profiled the tumor metastasis-associated microbiome in a pancancer cohort of 4,160 biopsies from 26 canc …
Advances in molecular glues: exploring chemical space and design principles for targeted protein degradation.
Hemant Kumar S, Venkatachalapathy M, Sistla R, Poongavanam V. Hemant Kumar S, et al. Drug Discov Today. 2024 Nov;29(11):104205. doi: 10.1016/j.drudis.2024.104205. Epub 2024 Oct 10. Drug Discov Today. 2024. PMID: 39393773 Free article. Review.
Recently, the emergence of low-molecular-weight molecular glue degraders (MGDs) has expanded the TPD landscape, because MGDs operate via the same mechanism while offering attractive physicochemical properties that are consistent with small-molecule therapeutics. ...
Recently, the emergence of low-molecular-weight molecular glue degraders (MGDs) has expanded the TPD landscape, because MGDs operate via the …
Organoids and organs-on-chips: Recent advances, applications in drug development, and regulatory challenges.
Zhou L, Huang J, Li C, Gu Q, Li G, Li ZA, Xu J, Zhou J, Tuan RS. Zhou L, et al. Med. 2025 Apr 11;6(4):100667. doi: 10.1016/j.medj.2025.100667. Med. 2025. PMID: 40220744 Review.
They can mimic complex physiological functions and pathological conditions, offering more realistic platforms for disease modeling, drug screening, precision medicine, and regenerative therapies. ...
They can mimic complex physiological functions and pathological conditions, offering more realistic platforms for disease modeling, d …
Hypoxia-inducible factor orchestrates adenosine metabolism to promote liver cancer development.
Cheu JW, Chiu DK, Kwan KK, Yang C, Yuen VW, Goh CC, Chui NN, Shen W, Law CT, Li Q, Zhang MS, Bao MH, Wong BP, Chan CY, Liu CX, Sit GF, Ooi ZY, Deng H, Tse AP, Ng IO, Wong CC. Cheu JW, et al. Sci Adv. 2023 May 5;9(18):eade5111. doi: 10.1126/sciadv.ade5111. Epub 2023 May 5. Sci Adv. 2023. PMID: 37146141 Free PMC article.
We illustrated the dual role of hypoxia in establishing an adenosine-mediated immunosuppressive TME and offered a potential therapeutic approach that synergizes with ICIs in HCC....
We illustrated the dual role of hypoxia in establishing an adenosine-mediated immunosuppressive TME and offered a potential therapeut …
Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management.
Stroes ES, Thompson PD, Corsini A, Vladutiu GD, Raal FJ, Ray KK, Roden M, Stein E, Tokgözoğlu L, Nordestgaard BG, Bruckert E, De Backer G, Krauss RM, Laufs U, Santos RD, Hegele RA, Hovingh GK, Leiter LA, Mach F, März W, Newman CB, Wiklund O, Jacobson TA, Catapano AL, Chapman MJ, Ginsberg HN; European Atherosclerosis Society Consensus Panel. Stroes ES, et al. Eur Heart J. 2015 May 1;36(17):1012-22. doi: 10.1093/eurheartj/ehv043. Epub 2015 Feb 18. Eur Heart J. 2015. PMID: 25694464 Free PMC article. Review.
The Panel recommends a structured work-up to identify individuals with clinically relevant SAMS generally to at least three different statins, so that they can be offered therapeutic regimens to satisfactorily address their cardiovascular risk. Further research into the un …
The Panel recommends a structured work-up to identify individuals with clinically relevant SAMS generally to at least three different statin …
A Clinical Practice Guideline for the Management of Patients With Degenerative Cervical Myelopathy: Recommendations for Patients With Mild, Moderate, and Severe Disease and Nonmyelopathic Patients With Evidence of Cord Compression.
Fehlings MG, Tetreault LA, Riew KD, Middleton JW, Aarabi B, Arnold PM, Brodke DS, Burns AS, Carette S, Chen R, Chiba K, Dettori JR, Furlan JC, Harrop JS, Holly LT, Kalsi-Ryan S, Kotter M, Kwon BK, Martin AR, Milligan J, Nakashima H, Nagoshi N, Rhee J, Singh A, Skelly AC, Sodhi S, Wilson JR, Yee A, Wang JC. Fehlings MG, et al. Global Spine J. 2017 Sep;7(3 Suppl):70S-83S. doi: 10.1177/2192568217701914. Epub 2017 Sep 5. Global Spine J. 2017. PMID: 29164035 Free PMC article.
RESULTS: Our recommendations were as follows: (1) "We recommend surgical intervention for patients with moderate and severe DCM." (2) "We suggest offering surgical intervention or a supervised trial of structured rehabilitation for patients with mild DCM. If initial nonope …
RESULTS: Our recommendations were as follows: (1) "We recommend surgical intervention for patients with moderate and severe DCM." (2) "We su …
2,019 results