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Page 1
Showing results for oca b
Search for Olca B instead (2 results)
OCA-B does not act as a transcriptional coactivator in T cells.
Lombard-Vadnais F, Lacombe J, Chabot-Roy G, Ferron M, Lesage S. Lombard-Vadnais F, et al. Immunol Cell Biol. 2022 May;100(5):338-351. doi: 10.1111/imcb.12543. Epub 2022 Mar 30. Immunol Cell Biol. 2022. PMID: 35285071
Pou2af1 encodes for OCA-B, a coactivator of OCT-1/2 transcription factors, which plays a key role in B-cell maturation. ...Overall, this study provides strong evidence that Pou2af1 does not act as a transcriptional coactivator in T cells, and conclusively demonstrat …
Pou2af1 encodes for OCA-B, a coactivator of OCT-1/2 transcription factors, which plays a key role in B-cell maturation. ...Ove …
OCA-B regulation of B-cell development and function.
Teitell MA. Teitell MA. Trends Immunol. 2003 Oct;24(10):546-53. doi: 10.1016/j.it.2003.08.002. Trends Immunol. 2003. PMID: 14552839 Review.
OCA-B probably exerts its effects through the regulation of octamer-motif controlled gene expression. The OCA-B gene encodes two proteins of distinct molecular weight, designated p34 and p35. ...
OCA-B probably exerts its effects through the regulation of octamer-motif controlled gene expression. The OCA-B …
OCA-B promotes pathogenic maturation of stem-like CD4+ T cells and autoimmune demyelination.
Hughes EP, Syage AR, Mirzaei Mehrabad E, Lane TE, Spike BT, Tantin D. Hughes EP, et al. J Clin Invest. 2025 Apr 29;135(13):e187862. doi: 10.1172/JCI187862. eCollection 2025 Jul 1. J Clin Invest. 2025. PMID: 40299553 Free PMC article.
In a relapsing-remitting EAE model, OCA-B loss protects mice specifically at relapse. During remission, OCA-B promotes the expression of Tcf7, Slamf6, and Sell in proliferating CNS T cell populations. ...These results identify OCA-B as a …
In a relapsing-remitting EAE model, OCA-B loss protects mice specifically at relapse. During remission, OCA-B pr …
OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage.
Wu XS, He XY, Ipsaro JJ, Huang YH, Preall JB, Ng D, Shue YT, Sage J, Egeblad M, Joshua-Tor L, Vakoc CR. Wu XS, et al. Nature. 2022 Jul;607(7917):169-175. doi: 10.1038/s41586-022-04842-7. Epub 2022 May 16. Nature. 2022. PMID: 35576971 Free PMC article.
OCA-T1 and OCA-T2 are paralogues of the B-cell-specific coactivator OCA-B; all three proteins are encoded in a gene cluster and contain a conserved peptide that binds to class II POU transcription factors and a DNA octamer motif in a bivalent manner. ...
OCA-T1 and OCA-T2 are paralogues of the B-cell-specific coactivator OCA-B; all three proteins are encoded in a gene cluster an …
Transcriptional co-regulator OCA-B/Pou2af1 restricts Th2 differentiation.
Hughes EP, Manna AK, Sun W, Osburn-Staker SM, Aamodt S, Warren KJ, Cox JE, Tantin D. Hughes EP, et al. Front Immunol. 2025 Apr 29;16:1548636. doi: 10.3389/fimmu.2025.1548636. eCollection 2025. Front Immunol. 2025. PMID: 40364837 Free PMC article.
RESULTS: We find that OCA-B indirectly associates with GATA3. ChIP-seq analysis reveals coenrichment of Gata3 and the transcription factor Oct1, a partner protein of OCA-B, at genomic locations responsible for the Th2 program including Il4, Il13, Il5, …
RESULTS: We find that OCA-B indirectly associates with GATA3. ChIP-seq analysis reveals coenrichment of Gata3 and the transcri …
OCA-B/Pou2af1 is sufficient to promote CD4(+) T cell memory and prospectively identifies memory precursors.
Sun W, Hughes EP, Kim H, Perovanovic J, Charley KR, Perkins B, Du J, Ibarra A, Syage AR, Hale JS, Williams MA, Tantin D. Sun W, et al. Proc Natl Acad Sci U S A. 2024 Feb 27;121(9):e2309153121. doi: 10.1073/pnas.2309153121. Epub 2024 Feb 22. Proc Natl Acad Sci U S A. 2024. PMID: 38386711 Free PMC article.
At peak viral response, short-lived effector T cell populations are expanded but show increased Gadd45b and Socs2 expression, while memory precursor effector cells show increased expression of Bcl2, Il7r, and Tcf7 on a per-cell basis. Using an OCA-B mCherry reporter …
At peak viral response, short-lived effector T cell populations are expanded but show increased Gadd45b and Socs2 expression, while memory p …
Targeting transcriptional coregulator OCA-B/Pou2af1 blocks activated autoreactive T cells in the pancreas and type 1 diabetes.
Kim H, Perovanovic J, Shakya A, Shen Z, German CN, Ibarra A, Jafek JL, Lin NP, Evavold BD, Chou DH, Jensen PE, He X, Tantin D. Kim H, et al. J Exp Med. 2021 Mar 1;218(3):e20200533. doi: 10.1084/jem.20200533. J Exp Med. 2021. PMID: 33295943 Free PMC article.
We hypothesized that T cell-specific OCA-B deletion and pharmacologic OCA-B inhibition would protect mice from autoimmune diabetes. ...Together, the results indicate that OCA-B is a potent autoimmune regulator and a promising target for p …
We hypothesized that T cell-specific OCA-B deletion and pharmacologic OCA-B inhibition would protect mice from a …
OCA-B promotes pathogenic maturation of stem-like CD4 (+) T cells and autoimmune demyelination.
Hughes EP, Syage AR, Mehrabad EM, Lane TE, Spike BT, Tantin D. Hughes EP, et al. bioRxiv [Preprint]. 2025 Mar 25:2023.11.29.569210. doi: 10.1101/2023.11.29.569210. bioRxiv. 2025. Update in: J Clin Invest. 2025 Apr 29;135(13):e187862. doi: 10.1172/JCI187862. PMID: 38076925 Free PMC article. Updated. Preprint.
In a relapsing-remitting EAE model, OCA-B loss protects mice specifically at relapse. During remission, OCA-B promotes the expression of Tcf7 , Slamf6 , and Sell in proliferating CNS T cell populations. ...These results identify OCA-B as …
In a relapsing-remitting EAE model, OCA-B loss protects mice specifically at relapse. During remission, OCA-B pr …
MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition.
Lu X, Chu CS, Fang T, Rayon-Estrada V, Fang F, Patke A, Qian Y, Clarke SH, Melnick AM, Zhang Y, Papavasiliou FN, Roeder RG. Lu X, et al. Cell Rep. 2019 Jul 9;28(2):472-485.e5. doi: 10.1016/j.celrep.2019.06.029. Cell Rep. 2019. PMID: 31291582 Free PMC article.
In addition, we find a strong synergy between MTA2 and OCA-B in repressing Igll1 and VpreB1 at the pre-B cell stage, and in regulating both the pre-B to immature B transition and splenic B cell development....
In addition, we find a strong synergy between MTA2 and OCA-B in repressing Igll1 and VpreB1 at the pre-B cell stage, and in re …
180 results