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3,549 results

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Page 1
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.
Mevissen TE, Hospenthal MK, Geurink PP, Elliott PR, Akutsu M, Arnaudo N, Ekkebus R, Kulathu Y, Wauer T, El Oualid F, Freund SM, Ovaa H, Komander D. Mevissen TE, et al. Cell. 2013 Jul 3;154(1):169-84. doi: 10.1016/j.cell.2013.05.046. Cell. 2013. PMID: 23827681 Free PMC article.
Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most members regulate cell-signaling cascades. ...Additional Ub-binding domains, the ubiquitinated sequence in the substrate, and defined S1' and S2 Ub-binding sites on the OTU domain ena …
Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most members regulate cell-signaling cascades. ...Addi …
OTU deubiquitinases in disease: roles and targeting.
Deng Y, Liu P. Deng Y, et al. Trends Mol Med. 2025 Jun 16:S1471-4914(25)00117-0. doi: 10.1016/j.molmed.2025.05.006. Online ahead of print. Trends Mol Med. 2025. PMID: 40527635 Review.
OTU dysregulation has been linked to diseases such as cancer, highlighting their potential as drug targets. This review summarizes current knowledge of OTU functions, regulatory mechanisms, and disease associations, as well as therapeutic strategies targeting OTUs. …
OTU dysregulation has been linked to diseases such as cancer, highlighting their potential as drug targets. This review summarizes cu …
The function and regulation of OTU deubiquitinases.
Du J, Fu L, Sui Y, Zhang L. Du J, et al. Front Med. 2020 Oct;14(5):542-563. doi: 10.1007/s11684-019-0734-4. Epub 2019 Dec 28. Front Med. 2020. PMID: 31884527 Review.
Recently, much progress has been made in the DUBs. In humans, the ovarian tumor protease (OTU) subfamily of DUBs includes 16 members, most of which mediate cell signaling cascades. ...
Recently, much progress has been made in the DUBs. In humans, the ovarian tumor protease (OTU) subfamily of DUBs includes 16 members, …
Bacterial usurpation of the OTU deubiquitinase fold.
Pruneda JN, Nguyen JV, Nagai H, Kubori T. Pruneda JN, et al. FEBS J. 2024 Aug;291(15):3303-3316. doi: 10.1111/febs.16725. Epub 2023 Jan 24. FEBS J. 2024. PMID: 36636866 Free PMC article. Review.
To exert control over host cellular functions, some pathogenic bacteria have usurped the OTU deubiquitinase fold as a secreted virulence factor that interferes with ubiquitination inside infected cells. ...Understanding bacterial OTU deubiquitinases holds the potent …
To exert control over host cellular functions, some pathogenic bacteria have usurped the OTU deubiquitinase fold as a secreted virule …
Viral OTU deubiquitinases: a structural and functional comparison.
Bailey-Elkin BA, van Kasteren PB, Snijder EJ, Kikkert M, Mark BL. Bailey-Elkin BA, et al. PLoS Pathog. 2014 Mar 27;10(3):e1003894. doi: 10.1371/journal.ppat.1003894. eCollection 2014 Mar. PLoS Pathog. 2014. PMID: 24676359 Free PMC article. Review.
Recent studies have revealed that proteases encoded by three very diverse RNA virus groups share structural similarity with enzymes of the Ovarian Tumor (OTU) superfamily of deubiquitinases (DUBs). The publication of the latest of these reports in quick succession prevente …
Recent studies have revealed that proteases encoded by three very diverse RNA virus groups share structural similarity with enzymes of the O …
Phylogeny-guided microbiome OTU-specific association test (POST).
Huang C, Callahan BJ, Wu MC, Holloway ST, Brochu H, Lu W, Peng X, Tzeng JY. Huang C, et al. Microbiome. 2022 Jun 7;10(1):86. doi: 10.1186/s40168-022-01266-3. Microbiome. 2022. PMID: 35668471 Free PMC article.
RESULTS: In this work, we propose a local collapsing test called phylogeny-guided microbiome OTU-specific association test (POST). In POST, whether or not to borrow information and how much information to borrow from the neighboring OTUs in the phylogenetic tree are superv …
RESULTS: In this work, we propose a local collapsing test called phylogeny-guided microbiome OTU-specific association test (POST). In …
Characterisation of the OTU domain deubiquitinase complement of Toxoplasma gondii.
Wilde ML, Ruparel U, Klemm T, Lee VV, Calleja DJ, Komander D, Tonkin CJ. Wilde ML, et al. Life Sci Alliance. 2023 Mar 23;6(6):e202201710. doi: 10.26508/lsa.202201710. Print 2023 Jun. Life Sci Alliance. 2023. PMID: 36958824 Free PMC article.
This study presents comprehensive characterisation of Toxoplasma OTU DUBs. AlphaFold-guided structural analysis not only confirmed functional orthologues found across eukaryotes, but also identified apicomplexan-specific enzymes, subsequently enabling discovery of a crypti …
This study presents comprehensive characterisation of Toxoplasma OTU DUBs. AlphaFold-guided structural analysis not only confirmed fu …
Dissecting the dual role of OTU family proteins in tumor progression and immune escape.
Tang X, Li Y, Liu Y. Tang X, et al. Front Immunol. 2025 May 21;16:1544341. doi: 10.3389/fimmu.2025.1544341. eCollection 2025. Front Immunol. 2025. PMID: 40469292 Free PMC article. Review.
As a core mechanism regulating intracellular protein homeostasis, the dynamic equilibrium between ubiquitination and deubiquitination profoundly impacts the functionality and fate of target proteins. The Ovarian tumor domain (OTU) family, a vital subclass of deubiquitinati …
As a core mechanism regulating intracellular protein homeostasis, the dynamic equilibrium between ubiquitination and deubiquitination profou …
Identification and characterization of diverse OTU deubiquitinases in bacteria.
Schubert AF, Nguyen JV, Franklin TG, Geurink PP, Roberts CG, Sanderson DJ, Miller LN, Ovaa H, Hofmann K, Pruneda JN, Komander D. Schubert AF, et al. EMBO J. 2020 Aug 3;39(15):e105127. doi: 10.15252/embj.2020105127. Epub 2020 Jun 22. EMBO J. 2020. PMID: 32567101 Free PMC article.
By removing host ubiquitin signals, for example, invading pathogens can inactivate immune response pathways and evade detection. The ovarian tumor (OTU) family of deubiquitinases regulates diverse ubiquitin signals in humans. Viral pathogens have also extensively co-opted …
By removing host ubiquitin signals, for example, invading pathogens can inactivate immune response pathways and evade detection. The ovarian …
Otu and Rif1 Double Mutant Enables Analysis of Satellite DNA in Polytene Chromosomes of Ovarian Germ Cells in Drosophila melanogaster.
Kolesnikova TD, Nokhova AR, Shatskikh AS, Klenov MS, Zhimulev IF. Kolesnikova TD, et al. Dokl Biochem Biophys. 2023 Dec;513(Suppl 1):S87-S91. doi: 10.1134/S160767292360046X. Epub 2024 Feb 9. Dokl Biochem Biophys. 2023. PMID: 38337102
Here, we investigated the impact of the Rif1 mutation on heterochromatin in polytene chromosomes formed in ovarian germ cells due to the otu gene mutation. By the analysis of otu(11); Rif1(1) double mutants, we found that, in the presence of the Rif1 mutation, ovari …
Here, we investigated the impact of the Rif1 mutation on heterochromatin in polytene chromosomes formed in ovarian germ cells due to the …
3,549 results