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Observational Study
. 2020 Nov 15:418:117090.
doi: 10.1016/j.jns.2020.117090. Epub 2020 Aug 11.

Cerebrospinal fluid findings in COVID-19 patients with neurological symptoms

Bernhard Neumann  1 , Moritz L Schmidbauer  2 , Konstatinos Dimitriadis  3 , Sören Otto  4 , Benjamin Knier  5 , Wolf-Dirk Niesen  6 , Jonas A Hosp  7 , Albrecht Günther  8 , Sarah Lindemann  9 , Gabor Nagy  10 , Tim Steinberg  11 , Ralf A Linker  12 , Bernhard Hemmer  13 , Julian Bösel  14 ; PANDEMIC and the IGNITE study groups
Affiliations
Observational Study

Cerebrospinal fluid findings in COVID-19 patients with neurological symptoms

Bernhard Neumann et al. J Neurol Sci. .

Abstract

  1. •

    Largest cohort of patients with COVID-19 and neurological symptoms who underwent LP.

  2. •

    In all 30 cases, RT-PCR for SARS-CoV-2 from CSF was negative.

  3. •

    CSF analysis findings, including WBC, were normal in most patients with COVID-19.

  4. •

    Neurological symptoms in COVID-19 seem to be caused mainly by indirect mechanism.

Keywords: COVID-19; Cerebrospinal fluid; Neurological symptoms; SARS-CoV-2.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1
Cerebrospinal fluid findings in COVID-19 patients with neurological symptoms. CSF cell count (n = 30) (A), CSF protein levels (n = 23) (B), CSF lactate levels (n = 16) (C) and albumin ratio (n = 25) of patients with COVID-19 infection. Empty dots (circle) are pathological results (A-C). In D grey dots symbolize intermediate blood brain barrier disruption and empty dots (circle) severe blood brain barrier disruption. CSF = cerebrospinal fluid, HSVE = herpes simplex virus encephalitis, ICH = intracranial hemorrhage.
See this image and copyright information in PMC

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