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Extended interaction networks with HCV protease NS3-4A substrates explain the lack of adaptive capability against protease inhibitors.
Dultz G, Shimakami T, Schneider M, Murai K, Yamane D, Marion A, Zeitler TM, Stross C, Grimm C, Richter RM, Bäumer K, Yi M, Biondi RM, Zeuzem S, Tampé R, Antes I, Lange CM, Welsch C. Dultz G, et al. J Biol Chem. 2020 Oct 2;295(40):13862-13874. doi: 10.1074/jbc.RA120.013898. Epub 2020 Aug 3. J Biol Chem. 2020. PMID: 32747444 Free PMC article.