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The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner.
Sanz-Castillo B, Hurtado B, Vara-Ciruelos D, El Bakkali A, Hermida D, Salvador-Barbero B, Martínez-Alonso D, González-Martínez J, Santiveri C, Campos-Olivas R, Ximénez-Embún P, Muñoz J, Álvarez-Fernández M, Malumbres M. Sanz-Castillo B, et al. EMBO J. 2023 Jan 16;42(2):e110833. doi: 10.15252/embj.2022110833. Epub 2022 Nov 10. EMBO J. 2023. PMID: 36354735 Free PMC article.
How activating mutations affect MEK1 regulation and function.
Jindal GA, Goyal Y, Humphreys JM, Yeung E, Tian K, Patterson VL, He H, Burdine RD, Goldsmith EJ, Shvartsman SY. Jindal GA, et al. J Biol Chem. 2017 Nov 17;292(46):18814-18820. doi: 10.1074/jbc.C117.806067. Epub 2017 Oct 10. J Biol Chem. 2017. PMID: 29018093 Free PMC article.
The importance of intrinsic disorder for protein phosphorylation.
Iakoucheva LM, Radivojac P, Brown CJ, O'Connor TR, Sikes JG, Obradovic Z, Dunker AK. Iakoucheva LM, et al. Nucleic Acids Res. 2004 Feb 11;32(3):1037-49. doi: 10.1093/nar/gkh253. Print 2004. Nucleic Acids Res. 2004. PMID: 14960716 Free PMC article.