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Use of the fused NS4A peptide-NS3 protease domain to study the importance of the helicase domain for protease inhibitor binding to hepatitis C virus NS3-NS4A.
Biochemistry. 2009 Feb 3;48(4):744-53. doi: 10.1021/bi801931e.
Biochemistry. 2009.
PMID: 19119853
Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663.
Maga G, Gemma S, Fattorusso C, Locatelli GA, Butini S, Persico M, Kukreja G, Romano MP, Chiasserini L, Savini L, Novellino E, Nacci V, Spadari S, Campiani G.
Maga G, et al.
Biochemistry. 2005 Jul 19;44(28):9637-44. doi: 10.1021/bi047437u.
Biochemistry. 2005.
PMID: 16008349
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Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase.
Yao N, Reichert P, Taremi SS, Prosise WW, Weber PC.
Yao N, et al.
Structure. 1999 Nov 15;7(11):1353-63. doi: 10.1016/s0969-2126(00)80025-8.
Structure. 1999.
PMID: 10574797
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