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. 2001 Oct;8(10):853-7.
doi: 10.1038/nsb1001-853.

Ca2+-independent binding of an EF-hand domain to a novel motif in the alpha-actinin-titin complex

R A Atkinson  1 , C Joseph, G Kelly, F W Muskett, T A Frenkiel, D Nietlispach, A Pastore
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Ca2+-independent binding of an EF-hand domain to a novel motif in the alpha-actinin-titin complex

R A Atkinson et al. Nat Struct Biol. 2001 Oct.

Abstract

The interaction between alpha-actinin and titin, two modular muscle proteins, is essential for sarcomere assembly. We have solved the solution structure of a complex between the calcium-insensitive C-terminal EF-hand domain of alpha-actinin-2 and the seventh Z-repeat of titin. The structure of the complex is in a semi-open conformation and closely resembles that of myosin light chains in their complexes with heavy chain IQ motifs. However, no IQ motif is present in the Z-repeat, suggesting that the semi-open conformation is a general structural solution for calcium-independent recognition of EF-hand domains.

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