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In silico and crystallographic studies identify key structural features of biliverdin IXβ reductase inhibitors having nanomolar potency.
J Biol Chem. 2018 Apr 13;293(15):5431-5446. doi: 10.1074/jbc.RA118.001803. Epub 2018 Feb 27.
J Biol Chem. 2018.
PMID: 29487133
Free PMC article.
N-H...O, O-H...O, and C-H...O hydrogen bonds in protein-ligand complexes: strong and weak interactions in molecular recognition.
Sarkhel S, Desiraju GR.
Sarkhel S, et al.
Proteins. 2004 Feb 1;54(2):247-59. doi: 10.1002/prot.10567.
Proteins. 2004.
PMID: 14696187
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Structure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme.
Pereira PJ, Macedo-Ribeiro S, Párraga A, Pérez-Luque R, Cunningham O, Darcy K, Mantle TJ, Coll M.
Pereira PJ, et al.
Nat Struct Biol. 2001 Mar;8(3):215-20. doi: 10.1038/84948.
Nat Struct Biol. 2001.
PMID: 11224564
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