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NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90.
J Biol Chem. 2019 Nov 1;294(44):16010-16019. doi: 10.1074/jbc.RA119.009960. Epub 2019 Sep 9.
J Biol Chem. 2019.
PMID: 31501246
Free PMC article.
Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation.
Soldano KL, Jivan A, Nicchitta CV, Gewirth DT.
Soldano KL, et al.
J Biol Chem. 2003 Nov 28;278(48):48330-8. doi: 10.1074/jbc.M308661200. Epub 2003 Sep 11.
J Biol Chem. 2003.
PMID: 12970348
Free article.
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