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Discovery and evaluation of biphenyl derivatives of 2-iminobenzimidazoles as prototype dual PTP1B inhibitors and AMPK activators with in vivo antidiabetic activity.
Chem Biol Drug Des. 2023 Apr;101(4):896-914. doi: 10.1111/cbdd.14198. Epub 2023 Jan 29.
Chem Biol Drug Des. 2023.
PMID: 36546307
Allosteric inhibition of protein tyrosine phosphatase 1B.
Wiesmann C, Barr KJ, Kung J, Zhu J, Erlanson DA, Shen W, Fahr BJ, Zhong M, Taylor L, Randal M, McDowell RS, Hansen SK.
Wiesmann C, et al.
Nat Struct Mol Biol. 2004 Aug;11(8):730-7. doi: 10.1038/nsmb803. Epub 2004 Jul 18.
Nat Struct Mol Biol. 2004.
PMID: 15258570
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