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Structural optimization of a TNFR1-selective antagonistic TNFα mutant to create new-modality TNF-regulating biologics.
J Biol Chem. 2020 Jul 10;295(28):9379-9391. doi: 10.1074/jbc.RA120.012723. Epub 2020 May 12.
J Biol Chem. 2020.
PMID: 32398258
Free PMC article.
A trimeric structural fusion of an antagonistic tumor necrosis factor-α mutant enhances molecular stability and enables facile modification.
Inoue M, Ando D, Kamada H, Taki S, Niiyama M, Mukai Y, Tadokoro T, Maenaka K, Nakayama T, Kado Y, Inoue T, Tsutsumi Y, Tsunoda SI.
Inoue M, et al.
J Biol Chem. 2017 Apr 21;292(16):6438-6451. doi: 10.1074/jbc.M117.779686. Epub 2017 Feb 24.
J Biol Chem. 2017.
PMID: 28235800
Free PMC article.
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Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist.
Shibata H, Yoshioka Y, Ohkawa A, Minowa K, Mukai Y, Abe Y, Taniai M, Nomura T, Kayamuro H, Nabeshi H, Sugita T, Imai S, Nagano K, Yoshikawa T, Fujita T, Nakagawa S, Yamamoto A, Ohta T, Hayakawa T, Mayumi T, Vandenabeele P, Aggarwal BB, Nakamura T, Yamagata Y, Tsunoda S, Kamada H, Tsutsumi Y.
Shibata H, et al.
J Biol Chem. 2008 Jan 11;283(2):998-1007. doi: 10.1074/jbc.M707933200. Epub 2007 Nov 14.
J Biol Chem. 2008.
PMID: 18003610
Free article.
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