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. 2007 Feb;14(2):164-6.
doi: 10.1038/nsmb1190. Epub 2007 Jan 14.

Adenovirus type 11 binding alters the conformation of its receptor CD46

B David Persson  1 , Dirk M Reiter, Marko Marttila, Ya-Fang Mei, José M Casasnovas, Niklas Arnberg, Thilo Stehle
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Adenovirus type 11 binding alters the conformation of its receptor CD46

B David Persson et al. Nat Struct Mol Biol. 2007 Feb.

Abstract

Adenoviruses (Ads) are important human pathogens and valuable gene delivery vehicles. We report here the crystal structure of the species B Ad11 knob complexed with the Ad11-binding region of its receptor CD46. The conformation of bound CD46 differs profoundly from its unbound state, with the bent surface structure straightened into an elongated rod. This mechanism of interaction is likely to be conserved among many pathogens that target CD46 or related molecules.

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