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Inhibitors of androgen receptor activation function-2 (AF2) site identified through virtual screening.
J Med Chem. 2011 Sep 22;54(18):6197-205. doi: 10.1021/jm200532b. Epub 2011 Aug 29.
J Med Chem. 2011.
PMID: 21846139
A surface on the androgen receptor that allosterically regulates coactivator binding.
Estébanez-Perpiñá E, Arnold LA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJ.
Estébanez-Perpiñá E, et al.
Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16074-9. doi: 10.1073/pnas.0708036104. Epub 2007 Oct 2.
Proc Natl Acad Sci U S A. 2007.
PMID: 17911242
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