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. 2008 Jan 1;18(1):318-23.
doi: 10.1016/j.bmcl.2007.10.076. Epub 2007 Nov 19.

Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode

Richard M Angell  1 , Paul Bamborough, Anne Cleasby, Stuart G Cockerill, Katherine L Jones, Christopher J Mooney, Donald O Somers, Ann L Walker
Affiliations

Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode

Richard M Angell et al. Bioorg Med Chem Lett. .

Abstract

The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.

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