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Conformational dynamics of the TTD-PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability.
Houliston RS, Lemak A, Iqbal A, Ivanochko D, Duan S, Kaustov L, Ong MS, Fan L, Senisterra G, Brown PJ, Wang YX, Arrowsmith CH. Houliston RS, et al. J Biol Chem. 2017 Dec 22;292(51):20947-20959. doi: 10.1074/jbc.M117.799700. Epub 2017 Oct 26. J Biol Chem. 2017. PMID: 29074623 Free PMC article.