PDB/3L4D[Secondary Source ID] - Search Results

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Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase.

Sagatova AA, Keniya MV, Wilson RK, Monk BC, Tyndall JD. Sagatova AA, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):4982-9. doi: 10.1128/AAC.00925-15. Epub 2015 Jun 8. Antimicrob Agents Chemother. 2015. PMID: 26055382 Free PMC article.

Substrate preferences and catalytic parameters determined by structural characteristics of sterol 14alpha-demethylase (CYP51) from Leishmania infantum.

Hargrove TY, Wawrzak Z, Liu J, Nes WD, Waterman MR, Lepesheva GI. Hargrove TY, et al. J Biol Chem. 2011 Jul 29;286(30):26838-48. doi: 10.1074/jbc.M111.237099. Epub 2011 May 31. J Biol Chem. 2011. PMID: 21632531 Free PMC article.

Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis.

Hargrove TY, Friggeri L, Wawrzak Z, Qi A, Hoekstra WJ, Schotzinger RJ, York JD, Guengerich FP, Lepesheva GI. Hargrove TY, et al. J Biol Chem. 2017 Apr 21;292(16):6728-6743. doi: 10.1074/jbc.M117.778308. Epub 2017 Mar 3. J Biol Chem. 2017. PMID: 28258218 Free PMC article.

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