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A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells.
J Biol Chem. 2018 Jan 19;293(3):941-952. doi: 10.1074/jbc.M117.813428. Epub 2017 Nov 27.
J Biol Chem. 2018.
PMID: 29180448
Free PMC article.
Human framework adaptation of a mouse anti-human IL-13 antibody.
Fransson J, Teplyakov A, Raghunathan G, Chi E, Cordier W, Dinh T, Feng Y, Giles-Komar J, Gilliland G, Lollo B, Malia TJ, Nishioka W, Obmolova G, Zhao S, Zhao Y, Swanson RV, Almagro JC.
Fransson J, et al.
J Mol Biol. 2010 Apr 30;398(2):214-31. doi: 10.1016/j.jmb.2010.03.004. Epub 2010 Mar 10.
J Mol Biol. 2010.
PMID: 20226193
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Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface.
Kroh HK, Chandrasekaran R, Rosenthal K, Woods R, Jin X, Ohi MD, Nyborg AC, Rainey GJ, Warrener P, Spiller BW, Lacy DB.
Kroh HK, et al.
J Biol Chem. 2017 Sep 1;292(35):14401-14412. doi: 10.1074/jbc.M117.781112. Epub 2017 Jul 13.
J Biol Chem. 2017.
PMID: 28705932
Free PMC article.
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