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. 2010 Jul;17(7):891-3.
doi: 10.1038/nsmb.1859. Epub 2010 Jun 13.

Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat

Nereida Jiménez-Menéndez  1 , Pablo Fernández-Millán, Anna Rubio-Cosials, Carme Arnan, Julio Montoya, Howard T Jacobs, Pau Bernadó, Miquel Coll, Isabel Usón, Maria Solà
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Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat

Nereida Jiménez-Menéndez et al. Nat Struct Mol Biol. 2010 Jul.

Abstract

The regulation of mitochondrial DNA (mtDNA) processes is slowly being characterized at a structural level. We present here crystal structures of human mitochondrial regulator mTERF, a transcription termination factor also implicated in replication pausing, in complex with double-stranded DNA oligonucleotides containing the tRNA(Leu)(UUR) gene sequence. mTERF comprises nine left-handed helical tandem repeats that form a left-handed superhelix, the Zurdo domain.

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