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Biophysical characterization of full-length human phenylalanine hydroxylase provides a deeper understanding of its quaternary structure equilibrium.
J Biol Chem. 2019 Jun 28;294(26):10131-10145. doi: 10.1074/jbc.RA119.008294. Epub 2019 May 10.
J Biol Chem. 2019.
PMID: 31076506
Free PMC article.
A single amino acid substitution uncouples catalysis and allostery in an essential biosynthetic enzyme in Mycobacterium tuberculosis.
Jiao W, Fan Y, Blackmore NJ, Parker EJ.
Jiao W, et al.
J Biol Chem. 2020 May 8;295(19):6252-6262. doi: 10.1074/jbc.RA120.012605. Epub 2020 Mar 26.
J Biol Chem. 2020.
PMID: 32217694
Free PMC article.
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Tyrosine latching of a regulatory gate affords allosteric control of aromatic amino acid biosynthesis.
Cross PJ, Dobson RC, Patchett ML, Parker EJ.
Cross PJ, et al.
J Biol Chem. 2011 Mar 25;286(12):10216-24. doi: 10.1074/jbc.M110.209924. Epub 2011 Jan 30.
J Biol Chem. 2011.
PMID: 21282100
Free PMC article.
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