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A chimeric prokaryotic pentameric ligand-gated channel reveals distinct pathways of activation.
J Gen Physiol. 2015 Oct;146(4):323-40. doi: 10.1085/jgp.201511478.
J Gen Physiol. 2015.
PMID: 26415570
Free PMC article.
ELIC-α7 Nicotinic acetylcholine receptor (α7nAChR) chimeras reveal a prominent role of the extracellular-transmembrane domain interface in allosteric modulation.
Tillman TS, Seyoum E, Mowrey DD, Xu Y, Tang P.
Tillman TS, et al.
J Biol Chem. 2014 May 16;289(20):13851-7. doi: 10.1074/jbc.M113.524611. Epub 2014 Apr 2.
J Biol Chem. 2014.
PMID: 24695730
Free PMC article.
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Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine.
Pan J, Chen Q, Willenbring D, Yoshida K, Tillman T, Kashlan OB, Cohen A, Kong XP, Xu Y, Tang P.
Pan J, et al.
Nat Commun. 2012 Mar 6;3:714. doi: 10.1038/ncomms1703.
Nat Commun. 2012.
PMID: 22395605
Free PMC article.
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