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Epiregulin Recognition Mechanisms by Anti-epiregulin Antibody 9E5: STRUCTURAL, FUNCTIONAL, AND MOLECULAR DYNAMICS SIMULATION ANALYSES.
Kado Y, Mizohata E, Nagatoishi S, Iijima M, Shinoda K, Miyafusa T, Nakayama T, Yoshizumi T, Sugiyama A, Kawamura T, Lee YH, Matsumura H, Doi H, Fujitani H, Kodama T, Shibasaki Y, Tsumoto K, Inoue T. Kado Y, et al. J Biol Chem. 2016 Jan 29;291(5):2319-30. doi: 10.1074/jbc.M115.656009. Epub 2015 Dec 1. J Biol Chem. 2016. PMID: 26627827 Free PMC article.
A single ligand is sufficient to activate EGFR dimers.
Liu P, Cleveland TE 4th, Bouyain S, Byrne PO, Longo PA, Leahy DJ. Liu P, et al. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10861-6. doi: 10.1073/pnas.1201114109. Epub 2012 Jun 14. Proc Natl Acad Sci U S A. 2012. PMID: 22699492 Free PMC article.