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Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators.
J Biol Chem. 2017 Apr 14;292(15):6095-6107. doi: 10.1074/jbc.M116.758219. Epub 2017 Feb 14.
J Biol Chem. 2017.
PMID: 28196863
Free PMC article.
Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism.
Thangavelu K, Pan CQ, Karlberg T, Balaji G, Uttamchandani M, Suresh V, Schüler H, Low BC, Sivaraman J.
Thangavelu K, et al.
Proc Natl Acad Sci U S A. 2012 May 15;109(20):7705-10. doi: 10.1073/pnas.1116573109. Epub 2012 Apr 26.
Proc Natl Acad Sci U S A. 2012.
PMID: 22538822
Free PMC article.
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