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Dimerization of complement factor H-related proteins modulates complement activation in vivo.
Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4685-90. doi: 10.1073/pnas.1219260110. Epub 2013 Mar 4.
Proc Natl Acad Sci U S A. 2013.
PMID: 23487775
Free PMC article.
The solution structure of the complement deregulator FHR5 reveals a compact dimer and provides new insights into CFHR5 nephropathy.
Kadkhodayi-Kholghi N, Bhatt JS, Gor J, McDermott LC, Gale DP, Perkins SJ.
Kadkhodayi-Kholghi N, et al.
J Biol Chem. 2020 Nov 27;295(48):16342-16358. doi: 10.1074/jbc.RA120.015132. Epub 2020 Sep 14.
J Biol Chem. 2020.
PMID: 32928961
Free PMC article.
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Two distinct conformations of factor H regulate discrete complement-binding functions in the fluid phase and at cell surfaces.
Osborne AJ, Nan R, Miller A, Bhatt JS, Gor J, Perkins SJ.
Osborne AJ, et al.
J Biol Chem. 2018 Nov 2;293(44):17166-17187. doi: 10.1074/jbc.RA118.004767. Epub 2018 Sep 14.
J Biol Chem. 2018.
PMID: 30217822
Free PMC article.
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