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Targeting HECT-type E3 ligases - insights from catalysis, regulation and inhibitors.
FEBS Lett. 2017 Sep;591(17):2636-2647. doi: 10.1002/1873-3468.12775. Epub 2017 Aug 20.
FEBS Lett. 2017.
PMID: 28771691
Free article.
Review.
Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.
Maspero E, Valentini E, Mari S, Cecatiello V, Soffientini P, Pasqualato S, Polo S.
Maspero E, et al.
Nat Struct Mol Biol. 2013 Jun;20(6):696-701. doi: 10.1038/nsmb.2566. Epub 2013 May 5.
Nat Struct Mol Biol. 2013.
PMID: 23644597
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Analysis of ubiquitin recognition by the HECT ligase E6AP provides insight into its linkage specificity.
Ries LK, Sander B, Deol KK, Letzelter MA, Strieter ER, Lorenz S.
Ries LK, et al.
J Biol Chem. 2019 Apr 12;294(15):6113-6129. doi: 10.1074/jbc.RA118.007014. Epub 2019 Feb 8.
J Biol Chem. 2019.
PMID: 30737286
Free PMC article.
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