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Directed evolution of a picomolar-affinity, high-specificity antibody targeting phosphorylated tau.
J Biol Chem. 2018 Aug 3;293(31):12081-12094. doi: 10.1074/jbc.RA118.003557. Epub 2018 Jun 13.
J Biol Chem. 2018.
PMID: 29899114
Free PMC article.
An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition.
Shih HH, Tu C, Cao W, Klein A, Ramsey R, Fennell BJ, Lambert M, Ní Shúilleabháin D, Autin B, Kouranova E, Laxmanan S, Braithwaite S, Wu L, Ait-Zahra M, Milici AJ, Dumin JA, LaVallie ER, Arai M, Corcoran C, Paulsen JE, Gill D, Cunningham O, Bard J, Mosyak L, Finlay WJ.
Shih HH, et al.
J Biol Chem. 2012 Dec 28;287(53):44425-34. doi: 10.1074/jbc.M112.415935. Epub 2012 Nov 12.
J Biol Chem. 2012.
PMID: 23148212
Free PMC article.
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The Combining Sites of Anti-lipid A Antibodies Reveal a Widely Utilized Motif Specific for Negatively Charged Groups.
Haji-Ghassemi O, Müller-Loennies S, Rodriguez T, Brade L, Grimmecke HD, Brade H, Evans SV.
Haji-Ghassemi O, et al.
J Biol Chem. 2016 May 6;291(19):10104-18. doi: 10.1074/jbc.M115.712448. Epub 2016 Mar 1.
J Biol Chem. 2016.
PMID: 26933033
Free PMC article.
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