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Phosphatidylinositol 4,5-bisphosphate drives Ca2+-independent membrane penetration by the tandem C2 domain proteins synaptotagmin-1 and Doc2β.
J Biol Chem. 2019 Jul 12;294(28):10942-10953. doi: 10.1074/jbc.RA119.007929. Epub 2019 May 30.
J Biol Chem. 2019.
PMID: 31147445
Free PMC article.
The C2B domain is the primary Ca2+ sensor in DOC2B: a structural and functional analysis.
Giladi M, Michaeli L, Almagor L, Bar-On D, Buki T, Ashery U, Khananshvili D, Hirsch JA.
Giladi M, et al.
J Mol Biol. 2013 Nov 15;425(22):4629-41. doi: 10.1016/j.jmb.2013.08.017. Epub 2013 Aug 28.
J Mol Biol. 2013.
PMID: 23994332
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