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How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of Prothrombin.
J Biol Chem. 2016 Mar 18;291(12):6071-82. doi: 10.1074/jbc.M115.700401. Epub 2016 Jan 12.
J Biol Chem. 2016.
PMID: 26763231
Free PMC article.
The linker connecting the two kringles plays a key role in prothrombin activation.
Pozzi N, Chen Z, Pelc LA, Shropshire DB, Di Cera E.
Pozzi N, et al.
Proc Natl Acad Sci U S A. 2014 May 27;111(21):7630-5. doi: 10.1073/pnas.1403779111. Epub 2014 May 12.
Proc Natl Acad Sci U S A. 2014.
PMID: 24821807
Free PMC article.
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The Fragment 1 Region of Prothrombin Facilitates the Favored Binding of Fragment 12 to Zymogen and Enforces Zymogen-like Character in the Proteinase.
Bradford HN, Krishnaswamy S.
Bradford HN, et al.
J Biol Chem. 2016 May 20;291(21):11114-23. doi: 10.1074/jbc.M116.723072. Epub 2016 Mar 24.
J Biol Chem. 2016.
PMID: 27013660
Free PMC article.
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