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Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK).
J Biol Chem. 2018 Nov 2;293(44):16994-17007. doi: 10.1074/jbc.RA118.004101. Epub 2018 Sep 11.
J Biol Chem. 2018.
PMID: 30206123
Free PMC article.
Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing.
Gu X, Yan Y, Novick SJ, Kovach A, Goswami D, Ke J, Tan MHE, Wang L, Li X, de Waal PW, Webb MR, Griffin PR, Xu HE, Melcher K.
Gu X, et al.
J Biol Chem. 2017 Jul 28;292(30):12653-12666. doi: 10.1074/jbc.M117.793018. Epub 2017 Jun 14.
J Biol Chem. 2017.
PMID: 28615457
Free PMC article.
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Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
Yan Y, Zhou XE, Novick SJ, Shaw SJ, Li Y, Brunzelle JS, Hitoshi Y, Griffin PR, Xu HE, Melcher K.
Yan Y, et al.
J Biol Chem. 2019 Jan 18;294(3):953-967. doi: 10.1074/jbc.RA118.004883. Epub 2018 Nov 26.
J Biol Chem. 2019.
PMID: 30478170
Free PMC article.
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