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An engineered AAV targeting integrin alpha V beta 6 presents improved myotropism across species.
Nat Commun. 2024 Sep 11;15(1):7965. doi: 10.1038/s41467-024-52002-4.
Nat Commun. 2024.
PMID: 39261465
Free PMC article.
Structural determinants of integrin β-subunit specificity for latent TGF-β.
Dong X, Hudson NE, Lu C, Springer TA.
Dong X, et al.
Nat Struct Mol Biol. 2014 Dec;21(12):1091-6. doi: 10.1038/nsmb.2905. Epub 2014 Nov 10.
Nat Struct Mol Biol. 2014.
PMID: 25383667
Free PMC article.
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Molecular Basis of the Ligand Binding Specificity of αvβ8 Integrin.
Ozawa A, Sato Y, Imabayashi T, Uemura T, Takagi J, Sekiguchi K.
Ozawa A, et al.
J Biol Chem. 2016 May 27;291(22):11551-65. doi: 10.1074/jbc.M116.719138. Epub 2016 Mar 31.
J Biol Chem. 2016.
PMID: 27033701
Free PMC article.
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