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An atomic structure of human γ-secretase.
Bai XC, Yan C, Yang G, Lu P, Ma D, Sun L, Zhou R, Scheres SHW, Shi Y. Bai XC, et al. Nature. 2015 Sep 10;525(7568):212-217. doi: 10.1038/nature14892. Epub 2015 Aug 17. Nature. 2015. PMID: 26280335 Free PMC article.
A novel triazole, NMK-T-057, induces autophagic cell death in breast cancer cells by inhibiting γ-secretase-mediated activation of Notch signaling.
Das A, Narayanam MK, Paul S, Mukhnerjee P, Ghosh S, Dastidar DG, Chakrabarty S, Ganguli A, Basu B, Pal M, Chatterji U, Banerjee SK, Karmakar P, Kumar D, Chakrabarti G. Das A, et al. J Biol Chem. 2019 Apr 26;294(17):6733-6750. doi: 10.1074/jbc.RA119.007671. Epub 2019 Mar 1. J Biol Chem. 2019. PMID: 30824542 Free PMC article.