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Adapted ATPase domain communication overcomes the cytotoxicity of p97 inhibitors.
J Biol Chem. 2018 Dec 28;293(52):20169-20180. doi: 10.1074/jbc.RA118.004301. Epub 2018 Oct 31.
J Biol Chem. 2018.
PMID: 30381397
Free PMC article.
2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition.
Banerjee S, Bartesaghi A, Merk A, Rao P, Bulfer SL, Yan Y, Green N, Mroczkowski B, Neitz RJ, Wipf P, Falconieri V, Deshaies RJ, Milne JL, Huryn D, Arkin M, Subramaniam S.
Banerjee S, et al.
Science. 2016 Feb 19;351(6275):871-5. doi: 10.1126/science.aad7974. Epub 2016 Jan 28.
Science. 2016.
PMID: 26822609
Free PMC article.
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