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A single mutation increases heavy-chain heterodimer assembly of bispecific antibodies by inducing structural disorder in one homodimer species.
J Biol Chem. 2020 Jul 10;295(28):9392-9408. doi: 10.1074/jbc.RA119.012335. Epub 2020 May 13.
J Biol Chem. 2020.
PMID: 32404368
Free PMC article.
Immunoglobulin domain interface exchange as a platform technology for the generation of Fc heterodimers and bispecific antibodies.
Skegro D, Stutz C, Ollier R, Svensson E, Wassmann P, Bourquin F, Monney T, Gn S, Blein S.
Skegro D, et al.
J Biol Chem. 2017 Jun 9;292(23):9745-9759. doi: 10.1074/jbc.M117.782433. Epub 2017 Apr 27.
J Biol Chem. 2017.
PMID: 28450393
Free PMC article.
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